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Tbio
NEB
Nebulin

Protein Summary
Description
This giant muscle protein may be involved in maintaining the structural integrity of sarcomeres and the membrane system associated with the myofibrils. Binds and stabilize F-actin. This gene encodes nebulin, a giant protein component of the cytoskeletal matrix that coexists with the thick and thin filaments within the sarcomeres of skeletal muscle. In most vertebrates, nebulin accounts for 3 to 4% of the total myofibrillar protein. The encoded protein contains approximately 30-amino acid long modules that can be classified into 7 types and other repeated modules. Protein isoform sizes vary from 600 to 800 kD due to alternative splicing that is tissue-, species-,and developmental stage-specific. Of the 183 exons in the nebulin gene, at least 43 are alternatively spliced, although exons 143 and 144 are not found in the same transcript. Of the several thousand transcript variants predicted for nebulin, the RefSeq Project has decided to create three representative RefSeq records. Mutations ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000172853
  • ENSP00000172853
  • ENSG00000183091
  • ENST00000397345
  • ENSP00000380505
  • ENST00000409198
  • ENSP00000386259
  • ENST00000427231
  • ENSP00000416578
  • ENST00000603639
  • ENSP00000473894
  • ENST00000604864
  • ENSP00000474498

Symbol
  • NEM2
  • NEB177D
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.95
cell line
0.7
interacting protein
0.66
gene perturbation
0.61
trait
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 665.34   (req: < 5)
Gene RIFs: 32   (req: <= 3)
Antibodies: 112   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 665.34   (req: >= 5)
Gene RIFs: 32   (req: > 3)
Antibodies: 112   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (127)
ABTB2
Tdark
Novelty:  0.45729157
p_int:  0.999991217
p_ni:  0.000008701
p_wrong:  8.2e-8
Data Source:  BioPlex
RSPH6A
Tdark
Novelty:  0.03734897
p_int:  0.999984644
p_ni:  0.000013392
p_wrong:  0.000001964
Data Source:  BioPlex
MECOM
Tbio
Family:  TF; Epigenetic
Novelty:  0.00500501
p_int:  0.999983518
p_ni:  0.00001455
p_wrong:  0.000001931
Data Source:  BioPlex
PRKAB2
Tchem
Family:  Enzyme
Novelty:  0.02815065
p_int:  0.999179052
p_ni:  0.000061601
p_wrong:  0.000759347
Score:  0.269
Data Source:  BioPlex,STRINGDB
TTN
Tbio
Family:  Kinase
Novelty:  0.00040356
Score:  0.999
Data Source:  STRINGDB
MYL1
Tbio
Novelty:  0.00360262
Score:  0.996
Data Source:  STRINGDB
TNNC2
Tbio
Novelty:  0.07759506
Score:  0.992
Data Source:  STRINGDB
TMOD4
Tbio
Novelty:  0.00932697
Score:  0.983
Data Source:  STRINGDB
TMOD1
Tbio
Novelty:  0.01142927
Score:  0.983
Data Source:  STRINGDB
TPM2
Tbio
Novelty:  0.00406572
Score:  0.979
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Muscle contraction (R-HSA-397014)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Muscle contraction
Reactome
Striated Muscle Contraction
Name
Explore in Pharos
Explore in Source
Muscle contraction
Striated Muscle Contraction
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
4
3
4
87.8
mean reticulocyte volume
1
1
1
60.8
mean corpuscular hemoglobin concentration
1
1
1
58.1
muscle measurement
1
1
1
53.8
creatine kinase measurement
1
1
1
46
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
4
87.8
mean reticulocyte volume
1
60.8
mean corpuscular hemoglobin concentration
1
58.1
muscle measurement
1
53.8
creatine kinase measurement
1
46
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:97292
17996
Horse
nebulin
VGNC:20651
100057773
Cow
nebulin
VGNC:31977
407121
Opossum
nebulin
100014130
Anole lizard
nebulin
100563097
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Horse
nebulin
Cow
nebulin
Opossum
nebulin
Anole lizard
nebulin
Publication Statistics
PubMed Score 665.34
PubMed score by year
PubTator Score 136.91
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title