Tclin NDUFS8 NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial

Protein Summary

Description

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). May donate electrons to ubiquinone. This gene encodes a subunit of mitochondrial NADH:ubiquinone oxidoreductase, or Complex I, a multimeric enzyme of the respiratory chain responsible for NADH oxidation, ubiquinone reduction, and the ejection of protons from mitochondria. The encoded protein is involved in the binding of two of the six to eight iron-sulfur clusters of Complex I and, as such, is required in the electron transfer process. Mutations in this gene have been associated with Leigh syndrome. [provided by RefSeq, Mar 2010]

Uniprot Accession IDs

• O00217
• B2RB86
• Q0VDA8

Gene Name

• NDUFS8

Ensembl ID

• ENST00000313468
• ENSP00000315774
• ENSG00000110717

Symbol

• TYKY
• CI-23k
• CI23KD
• MC1DN2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.98
kinase perturbation	0.91
transcription factor perturbation	0.91
histone modification site profile	0.87
transcription factor binding site profile	0.7

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Reductase / Nadh Dehydrogenase [Ubiquinone] Iron-sulfur Protein 8, Mitochondrial

Protein / Oxidoreductase / Dehydrogenase / Nadh Dehydrogenase [Ubiquinone] Iron-sulfur Protein 8, Mitochondrial

DTO Classes

Protein / Enzyme / Oxidoreductase / Dehydrogenase / Nadh Dehydrogenase [Ubiquinone] Iron-sulfur Protein 8, Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.65   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 239   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.65   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 239   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1