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Tbio
NDUFAF5
Arginine-hydroxylase NDUFAF5, mitochondrial

Protein Summary
Description
Arginine hydroxylase involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I, MT-ND1) at early stages (PubMed:18940309, PubMed:27226634). Acts by mediating hydroxylation of 'Arg-111' of NDUFS7 (PubMed:27226634). May also have methyltransferase activity (Probable). The NADH-ubiquinone oxidoreductase complex (complex I) of the mitochondrial respiratory chain catalyzes the transfer of electrons from NADH to ubiquinone, and consists of at least 43 subunits. The complex is located in the inner mitochondrial membrane. This gene encodes a mitochondrial protein that is associated with the matrix face of the mitochondrial inner membrane and is required for complex I assembly. A mutation in this gene results in mitochondrial complex I deficiency. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000378106
  • ENSP00000367346
  • ENSG00000101247
  • ENST00000463598
  • ENSP00000420497

Symbol
  • C20orf7
  • C20orf7
  • MC1DN16
  • dJ842G6.1
  • bA526K24.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.82
cell type or tissue
0.74
transcription factor binding site profile
0.69
cellular component
0.65
cell line
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.83   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 107   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.83   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (129)
XRCC2
Tbio
Novelty:  0.00862049
p_int:  0.99995788
p_ni:  0.00002701
p_wrong:  0.00001511
Score:  0.735
Data Source:  BioPlex,STRINGDB
NDUFAF8
Tbio
Novelty:  1.48457646
p_int:  0.999912316
p_ni:  0.000087684
p_wrong:  1e-9
Score:  0.236
Data Source:  BioPlex,STRINGDB
NDUFS7
Tclin
Family:  Enzyme
Novelty:  0.01562198
p_int:  0.999586419
p_ni:  0.00041358
Score:  0.996
Data Source:  BioPlex,STRINGDB
HBB
Tbio
Novelty:  0.00049683
p_int:  0.999363987
p_ni:  0.000636013
Data Source:  BioPlex
MRPL38
Tdark
Novelty:  0.71587283
p_int:  0.998005838
p_ni:  0.001994161
p_wrong:  1e-9
Score:  0.174
Data Source:  BioPlex,STRINGDB
LNP1
Tdark
Novelty:  0.00457285
p_int:  0.997554476
p_ni:  0.002445518
p_wrong:  7e-9
Data Source:  BioPlex
NDUFAF4
Tclin
Family:  Enzyme
Novelty:  0.10799507
p_int:  0.997052394
p_ni:  0.002947535
p_wrong:  7.1e-8
Score:  0.981
Data Source:  BioPlex,Reactome,STRINGDB
NPPB
Tbio
Novelty:  0.00024947
p_int:  0.996831997
p_ni:  0.003167996
p_wrong:  6e-9
Data Source:  BioPlex
KLHL22
Tbio
Novelty:  0.24456252
p_int:  0.996485425
p_ni:  0.00351448
p_wrong:  9.5e-8
Data Source:  BioPlex
NPPA
Tchem
Novelty:  0.00046693
p_int:  0.995100116
p_ni:  0.00489985
p_wrong:  3.4e-8
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Complex I biogenesis (R-HSA-6799198)

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Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Complex I biogenesis
Reactome
Metabolism
Reactome
Respiratory electron transport
Reactome
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Reactome
The citric acid (TCA) cycle and respiratory electron transport
Name
Explore in Pharos
Explore in Source
Complex I biogenesis
Metabolism
Respiratory electron transport
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
The citric acid (TCA) cycle and respiratory electron transport
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NADH:ubiquinone oxidoreductase complex assembly factor 5
VGNC:6208
458103
Macaque
NADH:ubiquinone oxidoreductase complex assembly factor 5
694292
Mouse
MGI:1916737
69487
Rat
RGD:1309829
296190
Dog
NADH:ubiquinone oxidoreductase complex assembly factor 5
VGNC:43695
477150
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NADH:ubiquinone oxidoreductase complex assembly factor 5
Macaque
NADH:ubiquinone oxidoreductase complex assembly factor 5
Mouse
Rat
Dog
NADH:ubiquinone oxidoreductase complex assembly factor 5
Publication Statistics
PubMed Score 11.83
PubMed score by year
PubTator Score 7.60
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title