Tclin NDUFAF3 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3

Protein Summary

Description

Essential factor for the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). This gene encodes a mitochondrial complex I assembly protein that interacts with complex I subunits. Mutations in this gene cause mitochondrial complex I deficiency, a fatal neonatal disorder of the oxidative phosphorylation system. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2009]

Uniprot Accession IDs

• Q9BU61

Gene Name

• NDUFAF3

Ensembl ID

• ENST00000326912
• ENSP00000323003
• ENSG00000178057
• ENST00000326925
• ENSP00000323076
• ENST00000395458
• ENSP00000378843
• ENST00000451378
• ENSP00000402465

Symbol

• C3orf60
• 2P1
• E3-3
• C3orf60
• MC1DN18

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.93
transcription factor binding site profile	0.89
disease perturbation	0.83
histone modification site profile	0.78
interacting protein	0.78

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3022.38   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 74   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3022.38   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 74   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1