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Tclin
NDUFA7
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7

Protein Summary
Description
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. This gene encodes a subunit of NADH:ubiquinone oxidoreductase (complex I), which is a multiprotein complex located in the inner mitochondrial membrane. Complex I functions in the transfer of electrons from NADH to the respiratory chain. [provided by RefSeq, Mar 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301457
  • ENSP00000301457
  • ENSG00000267855
  • ENST00000593729
  • ENSP00000470962

Symbol
  • B14.5a
  • CI-B14.5a
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.98
disease perturbation
0.9
histone modification site profile
0.84
kinase perturbation
0.84
transcription factor binding site profile
0.84


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.31   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 231   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.31   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 231   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (162)
NDUFB7
Tclin
Family:  Enzyme
Novelty:  0.14580093
p_int:  0.999999735
p_ni:  2.65e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
NDUFB6
Tclin
Family:  Enzyme
Novelty:  0.075245
p_int:  0.999998725
p_ni:  0.000001275
Score:  0.999
Data Source:  BioPlex,STRINGDB
NDUFB11
Tclin
Family:  Enzyme
Novelty:  0.0401232
p_int:  0.999998576
p_ni:  0.000001424
Score:  0.999
Data Source:  BioPlex,STRINGDB
NDUFS4
Tclin
Family:  Enzyme
Novelty:  0.00787292
p_int:  0.999998116
p_ni:  0.000001884
Score:  0.999
Data Source:  BioPlex,STRINGDB
NDUFB8
Tclin
Family:  Enzyme
Novelty:  0.019021
p_int:  0.999997316
p_ni:  0.000002684
Score:  0.999
Data Source:  BioPlex,STRINGDB
NDUFB9
Tclin
Family:  Enzyme
Novelty:  0.00715628
p_int:  0.99999167
p_ni:  0.00000833
Score:  0.999
Data Source:  BioPlex,STRINGDB
NDUFB5
Tclin
Family:  Enzyme
Novelty:  0.0257403
p_int:  0.999960137
p_ni:  0.000039863
Score:  0.998
Data Source:  BioPlex,STRINGDB
NDUFC2
Tclin
Family:  Enzyme
Novelty:  0.08387385
p_int:  0.999948784
p_ni:  0.000051216
Score:  0.998
Data Source:  BioPlex,STRINGDB
NDUFV3
Tclin
Family:  Enzyme
Novelty:  0.15352039
p_int:  0.999907408
p_ni:  0.000092592
Score:  0.993
Data Source:  BioPlex,STRINGDB
NDUFAF2
Tclin
Novelty:  0.04815608
p_int:  0.999891702
p_ni:  0.000068838
p_wrong:  0.000039459
Score:  0.905
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (17)
Complex I biogenesis (R-HSA-6799198)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Complex I biogenesis
Reactome
Metabolism
Reactome
Respiratory electron transport
Reactome
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Reactome
The citric acid (TCA) cycle and respiratory electron transport
Name
Explore in Pharos
Explore in Source
Complex I biogenesis
Metabolism
Respiratory electron transport
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
The citric acid (TCA) cycle and respiratory electron transport
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
13
8
20
4
99.5
triglyceride measurement
9
3
12
98
apolipoprotein A 1 measurement
2
3
4
97.1
very long-chain saturated fatty acid measurement
3
2
0
10
91.9
red blood cell distribution width
2
2
3
90.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
20
4
99.5
triglyceride measurement
12
98
apolipoprotein A 1 measurement
4
97.1
very long-chain saturated fatty acid measurement
0
10
91.9
red blood cell distribution width
3
90.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NADH:ubiquinone oxidoreductase subunit A7
743262
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NADH:ubiquinone oxidoreductase subunit A7
Publication Statistics
PubMed Score 7.31
PubMed score by year
PubTator Score 1.45
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title