Tclin NDUFA7 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7

Protein Summary

Description

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. This gene encodes a subunit of NADH:ubiquinone oxidoreductase (complex I), which is a multiprotein complex located in the inner mitochondrial membrane. Complex I functions in the transfer of electrons from NADH to the respiratory chain. [provided by RefSeq, Mar 2011]

Uniprot Accession IDs

• O95182

Gene Name

• NDUFA7

Ensembl ID

• ENST00000301457
• ENSP00000301457
• ENSG00000267855
• ENST00000593729
• ENSP00000470962

Symbol

• B14.5a
• CI-B14.5a

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.98
disease perturbation	0.9
histone modification site profile	0.84
kinase perturbation	0.84
transcription factor binding site profile	0.84

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.32   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 231   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.32   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 231   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1