Tclin NDUFA6 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6

Protein Summary

Description

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. This gene encodes a member of the LYR family of proteins that contain a highly conserved tripeptide (LYR) motif near the N-terminus. The encoded protein is an accessory subunit of NADH: ubiquinone oxidorerductase (Complex I), which is the largest enzyme of the mitochondrial membrane respiratory chain. Complex I functions in electron transfer from NADH to the respiratory chain. [provided by RefSeq, Oct 2016]

Uniprot Accession IDs

• P56556
• B2RE54
• O43675
• Q6FGW0
• Q6IBT8
• Q6IC39

Gene Name

• NDUFA6

Ensembl ID

• ENST00000498737
• ENSP00000418842
• ENSG00000184983
• ENST00000605916
• ENSP00000475402
• ENSG00000272765
• ENST00000628740
• ENSP00000486781
• ENSG00000277365
• ENST00000630201
• ENSP00000487431
• ENSG00000281013
• ENST00000630971
• ENSP00000487462
• ENSG00000273397

Symbol

• LYRM6
• NADHB14
• B14
• LYRM6
• CI-B14
• MC1DN33
• NADHB14

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
kinase perturbation	0.95
virus perturbation	0.92
histone modification site profile	0.91
transcription factor binding site profile	0.82

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Dehydrogenase / Nadh Dehydrogenase [Ubiquinone] 1 Alpha Subcomplex Subunit 6

DTO Classes

Protein / Enzyme / Oxidoreductase / Dehydrogenase / Nadh Dehydrogenase [Ubiquinone] 1 Alpha Subcomplex Subunit 6

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 957   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 102   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 957   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 102   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1