You are using an outdated browser. Please upgrade your browser to improve your experience.

Tclin
NDUFA3
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3

Protein Summary
Description
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000419113
  • ENSP00000398290
  • ENSG00000170906
  • ENST00000485876
  • ENSP00000418438
  • ENST00000620289
  • ENSP00000477783
  • ENSG00000276061
  • ENST00000622523
  • ENSP00000483683

Symbol
  • B9
  • CI-B9
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.93
kinase perturbation
0.76
histone modification site profile
0.7
transcription factor perturbation
0.68
cellular component
0.67


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.02   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 118   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.02   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 118   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (144)
NDUFV3
Tclin
Family:  Enzyme
Novelty:  0.15352039
p_int:  0.999891094
p_ni:  0.000108906
Score:  0.993
Data Source:  BioPlex,STRINGDB
NDUFA8
Tclin
Family:  Enzyme
Novelty:  0.05772867
p_int:  0.996072398
p_ni:  0.003927376
p_wrong:  2.26e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
NDUFS3
Tclin
Family:  Enzyme
Novelty:  0.01968313
p_int:  0.99265766
p_ni:  0.00734234
Score:  0.998
Data Source:  BioPlex,STRINGDB
ECSIT
Tbio
Novelty:  0.04690184
p_int:  0.990751949
p_ni:  0.009242862
p_wrong:  0.000005189
Score:  0.974
Data Source:  BioPlex,STRINGDB
NDUFA13
Tclin
Family:  Enzyme
Novelty:  0.01605077
p_int:  0.982969856
p_ni:  0.017007493
p_wrong:  0.000022651
Score:  0.999
Data Source:  BioPlex,STRINGDB
NDUFB11
Tclin
Family:  Enzyme
Novelty:  0.0401232
p_int:  0.976861858
p_ni:  0.023068874
p_wrong:  0.000069268
Score:  0.994
Data Source:  BioPlex,STRINGDB
GAL3ST1
Tbio
Family:  Enzyme
Novelty:  0.02939055
p_int:  0.969279406
p_ni:  0.030720433
p_wrong:  1.61e-7
Score:  0.204
Data Source:  BioPlex,STRINGDB
NDUFA7
Tclin
Family:  Enzyme
Novelty:  0.16417588
p_int:  0.967987952
p_ni:  0.032006345
p_wrong:  0.000005703
Score:  0.999
Data Source:  BioPlex,STRINGDB
ACVR2B
Tchem
Family:  Kinase
Novelty:  0.00555742
p_int:  0.930788853
p_ni:  0.069112868
p_wrong:  0.000098279
Data Source:  BioPlex
NRROS
Tbio
Novelty:  0.08976002
p_int:  0.925189218
p_ni:  0.074810756
p_wrong:  2.6e-8
Score:  0.183
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (17)
Complex I biogenesis (R-HSA-6799198)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Complex I biogenesis
Reactome
Metabolism
Reactome
Respiratory electron transport
Reactome
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Reactome
The citric acid (TCA) cycle and respiratory electron transport
Name
Explore in Pharos
Explore in Source
Complex I biogenesis
Metabolism
Respiratory electron transport
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
The citric acid (TCA) cycle and respiratory electron transport
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (138)
Items per page:
1 – 5 of 138
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
2
3
3
18.1
97.7
alkaline phosphatase measurement
2
3
3
18.1
97.7
blood metabolite measurement
2
2
2
89.9
blood metabolite measurement
2
2
2
89.9
phosphatidylinositol measurement
1
1
3
78.4
Items per page:
1 – 5 of 138
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
3
18.1
97.7
alkaline phosphatase measurement
3
18.1
97.7
blood metabolite measurement
2
89.9
blood metabolite measurement
2
89.9
phosphatidylinositol measurement
3
78.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NADH:ubiquinone oxidoreductase subunit A3
VGNC:11198
100614219
Mouse
MGI:1913341
66091
Rat
RGD:1594144
680288
Horse
NADH:ubiquinone oxidoreductase subunit A3
VGNC:20624
100052169
Opossum
NADH:ubiquinone oxidoreductase subunit A3
100028584
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NADH:ubiquinone oxidoreductase subunit A3
Mouse
Rat
Horse
NADH:ubiquinone oxidoreductase subunit A3
Opossum
NADH:ubiquinone oxidoreductase subunit A3
Publication Statistics
PubMed Score 3.02
PubMed score by year
PubTator Score 40.25
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title