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Tbio
NDP
Norrin

Protein Summary
Description
Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). May be involved in a pathway that regulates neural cell differentiation and proliferation. Possible role in neuroectodermal cell-cell interaction. This gene encodes a secreted protein with a cystein-knot motif that activates the Wnt/beta-catenin pathway. The protein forms disulfide-linked oligomers in the extracellular matrix. Mutations in this gene result in Norrie disease and X-linked exudative vitreoretinopathy. [provided by RefSeq, Feb 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000378062
  • ENSP00000367301
  • ENSG00000124479
  • ENST00000642620
  • ENSP00000495972
  • ENST00000647044
  • ENSP00000495811

Symbol
  • EVR2
  • ND
  • EVR2
  • FEVR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
phenotype
0.6
biological process
0.59
gene perturbation
0.56
biological term
0.52
disease
0.52


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 134.56   (req: < 5)
Gene RIFs: 48   (req: <= 3)
Antibodies: 158   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 134.56   (req: >= 5)
Gene RIFs: 48   (req: > 3)
Antibodies: 158   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (84)
CACNA2D1
Tclin
Family:  IC
Novelty:  0.01744541
p_int:  0.99860819
p_ni:  0.00139181
Data Source:  BioPlex
LRP1B
Tbio
Novelty:  0.01443405
p_int:  0.992537783
p_ni:  0.007462217
Data Source:  BioPlex
VWDE
Tdark
Novelty:  0.37298162
p_int:  0.984845268
p_ni:  0.014927355
p_wrong:  0.000227377
Data Source:  BioPlex
TPPP2
Tdark
Novelty:  0.22245887
p_int:  0.982147047
p_ni:  0.017852953
Data Source:  BioPlex
TMEM67
Tbio
Novelty:  0.02573267
p_int:  0.973074447
p_ni:  0.026924228
p_wrong:  0.000001325
Score:  0.176
Data Source:  BioPlex,STRINGDB
MRC2
Tbio
Novelty:  0.01100289
p_int:  0.97272045
p_ni:  0.027278993
p_wrong:  5.57e-7
Data Source:  BioPlex
CD109
Tbio
Novelty:  0.01280272
p_int:  0.969073881
p_ni:  0.030925958
p_wrong:  1.61e-7
Data Source:  BioPlex
CACNA2D2
Tclin
Family:  IC
Novelty:  0.02041017
p_int:  0.968793421
p_ni:  0.031206579
Data Source:  BioPlex
ATRN
Tbio
Novelty:  0.01017312
p_int:  0.967688698
p_ni:  0.032311302
Data Source:  BioPlex
KDM5C
Tchem
Family:  TF; Epigenetic
Novelty:  0.00701855
p_int:  0.966046553
p_ni:  0.033953447
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: inoh
Heterotrimeric GPCR signaling pathway (through G alpha q, PLC beta and ERK cascade) ( GPCR signaling (G alpha q) )
PathwayCommons: inoh
Heterotrimeric GPCR signaling pathway (through G alpha s ACs Epac BRaf and ERKcascade) ( GPCR signaling (G alpha s, Epac and ERK) )
PathwayCommons: inoh
Heterotrimeric GTP-binding protein coupled receptor signaling pathway (through_G_alpha_s,_cholera_toxin,_adenylate_cyclase_and_cAMP) ( GPCR signaling (cholera toxin) )
PathwayCommons: inoh
Heterotrimeric GPCR signaling pathway (through G alpha i and pertussis toxin) ( GPCR signaling (pertussis toxin) )
PathwayCommons: inoh
Heterotrimeric GTP-binding protein coupled receptor signaling pathway (through G alpha i, adenylate cyclase and cAMP) ( GPCR signaling (G alpha i) )
Name
Explore in Pharos
Explore in Source
Heterotrimeric GPCR signaling pathway (through G alpha q, PLC beta and ERK cascade) ( GPCR signaling (G alpha q) )
Heterotrimeric GPCR signaling pathway (through G alpha s ACs Epac BRaf and ERKcascade) ( GPCR signaling (G alpha s, Epac and ERK) )
Heterotrimeric GTP-binding protein coupled receptor signaling pathway (through_G_alpha_s,_cholera_toxin,_adenylate_cyclase_and_cAMP) ( GPCR signaling (cholera toxin) )
Heterotrimeric GPCR signaling pathway (through G alpha i and pertussis toxin) ( GPCR signaling (pertussis toxin) )
Heterotrimeric GTP-binding protein coupled receptor signaling pathway (through G alpha i, adenylate cyclase and cAMP) ( GPCR signaling (G alpha i) )
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
3
6
95.2
mean arterial pressure
2
2
2
20
systolic blood pressure
1
1
1
1.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
6
95.2
mean arterial pressure
2
20
systolic blood pressure
1
1.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NDP, norrin cystine knot growth factor
VGNC:10469
107971189
Macaque
NDP, norrin cystine knot growth factor
702203
Mouse
MGI:102570
17986
Dog
NDP, norrin cystine knot growth factor
VGNC:43678
612440
Horse
NDP, norrin cystine knot growth factor
VGNC:20614
100050800
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NDP, norrin cystine knot growth factor
Macaque
NDP, norrin cystine knot growth factor
Mouse
Dog
NDP, norrin cystine knot growth factor
Horse
NDP, norrin cystine knot growth factor
Publication Statistics
PubMed Score 134.56
PubMed score by year
PubTator Score 334.59
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title