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Tbio
NDOR1
NADPH-dependent diflavin oxidoreductase 1

Protein Summary
Description
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins (By similarity). Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Transfers electrons from NADPH to the Fe/S cluster of CIAPIN1. This gene encodes an NADPH-dependent diflavin reductase that contains both flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD) binding domains. The encoded protein catalyzes the transfer of electrons from NADPH through FAD and FMN cofactors to potential redox partners. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000344894
  • ENSP00000343344
  • ENSG00000188566
  • ENST00000371521
  • ENSP00000360576
  • ENST00000427047
  • ENSP00000394309
  • ENST00000458322
  • ENSP00000389905

Symbol
  • NR1
  • NR1
  • CIAE1
  • bA350O14.9
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.91
histone modification site profile
0.74
gene perturbation
0.67
cell type or tissue
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.99   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 203   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.99   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 203   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (81)
SLBP
Tbio
Novelty:  0.00685735
p_int:  0.999981049
p_ni:  0.000012129
p_wrong:  0.000006823
Data Source:  BioPlex
CIAPIN1
Tbio
Novelty:  0.01359005
p_int:  0.999964066
p_ni:  0.000035932
p_wrong:  3e-9
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
ASPSCR1
Tbio
Novelty:  0.01172319
p_int:  0.999954103
p_ni:  0.000045897
Data Source:  BioPlex
ZNF148
Tbio
Family:  TF
Novelty:  0.01613534
p_int:  0.997914817
p_ni:  0.002085182
Data Source:  BioPlex
SPIN3
Tchem
Novelty:  0.16670763
p_int:  0.997878199
p_ni:  0.002121801
Data Source:  BioPlex
GNGT1
Tbio
Novelty:  0.05291961
p_int:  0.997658006
p_ni:  0.002341994
Data Source:  BioPlex
ARNT
Tbio
Family:  TF
Novelty:  0.00183071
p_int:  0.994344298
p_ni:  0.005655702
Data Source:  BioPlex
GLRX3
Tbio
Novelty:  0.0096265
p_int:  0.979438283
p_ni:  0.020561717
Score:  0.585
Data Source:  BioPlex,STRINGDB
MPLKIP
Tbio
Family:  Enzyme
Novelty:  0.01661924
p_int:  0.977538664
p_ni:  0.000001741
p_wrong:  0.022459595
Data Source:  BioPlex
LRRC41
Tbio
Novelty:  0.12601472
p_int:  0.905209015
p_ni:  0.094790985
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
Cytosolic iron-sulfur cluster assembly (R-HSA-2564830)

Click on a row in the table to change the structure displayed.

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Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytosolic iron-sulfur cluster assembly
Reactome
Metabolism
Name
Explore in Pharos
Explore in Source
Cytosolic iron-sulfur cluster assembly
Metabolism
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (14)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
4
4
5
89.9
creatinine measurement
2
4
5
81.6
blood protein measurement
1
1
1
78.5
reticulocyte measurement
3
1
3
72.7
reticulocyte count
6
1
6
70.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
5
89.9
creatinine measurement
5
81.6
blood protein measurement
1
78.5
reticulocyte measurement
3
72.7
reticulocyte count
6
70.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NADPH dependent diflavin oxidoreductase 1
VGNC:4798
736138
Macaque
NADPH dependent diflavin oxidoreductase 1
706056
Mouse
MGI:1926047
78797
Rat
RGD:1308479
311799
Dog
NADPH dependent diflavin oxidoreductase 1
VGNC:43677
491234
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NADPH dependent diflavin oxidoreductase 1
Macaque
NADPH dependent diflavin oxidoreductase 1
Mouse
Rat
Dog
NADPH dependent diflavin oxidoreductase 1
Publication Statistics
PubMed Score 8.99
PubMed score by year
PubTator Score 8.27
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title