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Tbio
NDN
Necdin

Protein Summary
Description
Growth suppressor that facilitates the entry of the cell into cell cycle arrest. Functionally similar to the retinoblastoma protein it binds to and represses the activity of cell-cycle-promoting proteins such as SV40 large T antigen, adenovirus E1A, and the transcription factor E2F. Necdin also interacts with p53 and works in an additive manner to inhibit cell growth. Functions also as transcription factor and binds directly to specific guanosine-rich DNA sequences (By similarity). This intronless gene is located in the Prader-Willi syndrome deletion region. It is an imprinted gene and is expressed exclusively from the paternal allele. Studies in mouse suggest that the protein encoded by this gene may suppress growth in postmitotic neurons. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000331837
  • ENSP00000332643
  • ENSG00000182636
  • ENST00000649030
  • ENSP00000497916

Symbol
  • PWCR
  • HsT16328
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.94
disease perturbation
0.87
PubMedID
0.86
kinase perturbation
0.76
biological process
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 233.74   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 336   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 233.74   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 336   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (94)
NGFR
Tclin
Novelty:  0.00072052
Score:  0.993
Data Source:  STRINGDB
E2F1
Tbio
Family:  TF
Novelty:  0.00277137
Score:  0.958
Data Source:  STRINGDB
STAT3
Tchem
Family:  TF
Novelty:  0.00011808
Score:  0.949
Data Source:  STRINGDB
SORT1
Tchem
Novelty:  0.00319862
Score:  0.933
Data Source:  STRINGDB
NGF
Tchem
Novelty:  0.00008139
Score:  0.933
Data Source:  STRINGDB
STAT6
Tchem
Family:  TF
Novelty:  0.00096732
Score:  0.902
Data Source:  STRINGDB
GNRH1
Tbio
Novelty:  0.00020807
Score:  0.874
Data Source:  STRINGDB
SNRPN
Tbio
Novelty:  0.002157
Score:  0.817
Data Source:  STRINGDB
TP53
Tchem
Family:  TF
Novelty:  0.00001907
Score:  0.809
Data Source:  STRINGDB
MKRN3
Tbio
Family:  Enzyme
Novelty:  0.01192486
Score:  0.797
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (73)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-4 and Interleukin-13 signaling
Reactome
Signaling by Interleukins
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interleukin-4 and Interleukin-13 signaling
Signaling by Interleukins
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
comparative body size at age 10, self-reported
1
1
1
9.3
high density lipoprotein cholesterol measurement
1
1
1
5.3
serum metabolite measurement
1
1
1
0.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
comparative body size at age 10, self-reported
1
9.3
high density lipoprotein cholesterol measurement
1
5.3
serum metabolite measurement
1
0.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
necdin, MAGE family member
574323
Mouse
MGI:97290
17984
Rat
RGD:1310526
308690
Dog
necdin, MAGE family member
VGNC:43675
488693
Horse
necdin, MAGE family member
VGNC:20612
100060951
Species
Name
OMA
EggNOG
Inparanoid
Macaque
necdin, MAGE family member
Mouse
Rat
Dog
necdin, MAGE family member
Horse
necdin, MAGE family member
Publication Statistics
PubMed Score 233.74
PubMed score by year
PubTator Score 90.92
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title