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Tbio
NDE1
Nuclear distribution protein nudE homolog 1

Protein Summary
Description
Required for centrosome duplication and formation and function of the mitotic spindle. Essential for the development of the cerebral cortex. May regulate the production of neurons by controlling the orientation of the mitotic spindle during division of cortical neuronal progenitors of the proliferative ventricular zone of the brain. Orientation of the division plane perpendicular to the layers of the cortex gives rise to two proliferative neuronal progenitors whereas parallel orientation of the division plane yields one proliferative neuronal progenitor and a post-mitotic neuron. A premature shift towards a neuronal fate within the progenitor population may result in an overall reduction in the final number of neurons and an increase in the number of neurons in the deeper layers of the cortex. This gene encodes a member of the nuclear distribution E (NudE) family of proteins. The encoded protein is localized at the centrosome and interacts with other centrosome components as part of a ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000396354
  • ENSP00000379642
  • ENSG00000072864
  • ENST00000396355
  • ENSP00000379643
  • ENST00000631844
  • ENSP00000488199
  • ENSG00000275911
  • ENST00000631923
  • ENSP00000488050

Symbol
  • NUDE
  • NDE
  • LIS4
  • MHAC
  • NUDE
  • NUDE1
  • HOM-TES-87
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.96
transcription factor binding site profile
0.9
histone modification site profile
0.83
cellular component
0.79
disease perturbation
0.79


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 193.33   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 252   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 193.33   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 252   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (298)
NDEL1
Tbio
Novelty:  0.01241819
p_int:  0.999998191
p_ni:  0.000001808
Score:  0.955
Data Source:  BioPlex,STRINGDB
DISC1
Tbio
Novelty:  0.00183442
p_int:  0.999955134
p_ni:  0.000044866
Score:  0.733
Data Source:  BioPlex,STRINGDB
NUP54
Tbio
Novelty:  0.08155008
p_int:  0.999723467
p_ni:  0.000276533
Score:  0.195
Data Source:  BioPlex,STRINGDB
CCSER1
Tbio
Novelty:  0.20244518
p_int:  0.999659694
p_ni:  0.000340306
Score:  0.816
Data Source:  BioPlex,STRINGDB
NPTX2
Tbio
Novelty:  0.00686292
p_int:  0.999570274
p_ni:  0.000429726
Data Source:  BioPlex
BORCS6
Tdark
Novelty:  0.83789033
p_int:  0.999002368
p_ni:  0.000997632
Data Source:  BioPlex
CCDC183
Tdark
Novelty:  1.55719016
p_int:  0.997106715
p_ni:  0.002893285
Data Source:  BioPlex
SNAP29
Tbio
Novelty:  0.02009206
p_int:  0.996359961
p_ni:  0.003640039
Score:  0.261
Data Source:  BioPlex,STRINGDB
BRK1
Tbio
Novelty:  0.02289534
p_int:  0.994883918
p_ni:  0.005116055
p_wrong:  2.7e-8
Data Source:  BioPlex
SYCE1
Tbio
Novelty:  0.05038876
p_int:  0.957696688
p_ni:  0.042303312
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (28)
AURKA Activation by TPX2 (R-HSA-8854518)

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Find Similar Targets
Items per page:
1 – 5 of 28
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AURKA Activation by TPX2
Reactome
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Reactome
Amplification of signal from the kinetochores
Reactome
Anchoring of the basal body to the plasma membrane
Reactome
Cell Cycle
Name
Explore in Pharos
Explore in Source
AURKA Activation by TPX2
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Amplification of signal from the kinetochores
Anchoring of the basal body to the plasma membrane
Cell Cycle
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (22)
Items per page:
1 – 5 of 22
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
skin aging measurement
1
1
1
52.7
skin aging measurement
1
1
1
52.7
inflammatory biomarker measurement
1
1
0
46.3
35
inflammatory biomarker measurement
1
1
0
46.3
35
pulse pressure measurement
1
1
1
30.9
Items per page:
1 – 5 of 22
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
skin aging measurement
1
52.7
skin aging measurement
1
52.7
inflammatory biomarker measurement
0
46.3
35
inflammatory biomarker measurement
0
46.3
35
pulse pressure measurement
1
30.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
nudE neurodevelopment protein 1
717754
Mouse
MGI:1914453
67203
Rat
RGD:620038
83836
Dog
nudE neurodevelopment protein 1
VGNC:43671
100684378
Horse
nudE neurodevelopment protein 1
VGNC:20609
100050421
Species
Name
OMA
EggNOG
Inparanoid
Macaque
nudE neurodevelopment protein 1
Mouse
Rat
Dog
nudE neurodevelopment protein 1
Horse
nudE neurodevelopment protein 1
Publication Statistics
PubMed Score 193.33
PubMed score by year
PubTator Score 51.07
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title