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Tbio
NDC80
Kinetochore protein NDC80 homolog

Protein Summary
Description
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:9315664, PubMed:12351790, PubMed:14654001, PubMed:14699129, PubMed:15062103, PubMed:15235793, PubMed:15239953, PubMed:15548592, PubMed:16732327). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:15548592). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020). Plays a role in chromosome congression and is essential for the end-on attachment of the kinetochores to spindle microtubules (PubMed:25743205, PubMed:23891108). This gene encodes a component of the NDC80 kinetochore complex. The encoded protein consists of an N-terminal microtubule binding domain and a C-terminal coiled-coiled domain that interacts with other c ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261597
  • ENSP00000261597
  • ENSG00000080986

Symbol
  • HEC
  • HEC1
  • KNTC2
  • HEC
  • HEC1
  • TID3
  • KNTC2
  • HsHec1
  • hsNDC80
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.97
interacting protein
0.89
histone modification site profile
0.85
gene perturbation
0.83
cellular component
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 289.92   (req: < 5)
Gene RIFs: 59   (req: <= 3)
Antibodies: 405   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 289.92   (req: >= 5)
Gene RIFs: 59   (req: > 3)
Antibodies: 405   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (387)
SPC24
Tbio
Novelty:  0.03166479
p_int:  0.999999816
p_ni:  1.84e-7
p_wrong:  1e-9
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
SPC25
Tbio
Novelty:  0.26354244
p_int:  0.999999749
p_ni:  2.51e-7
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
PMF1
Tbio
Novelty:  0.05319446
p_int:  0.99999808
p_ni:  0.00000192
Score:  0.49
Data Source:  BioPlex,Reactome,STRINGDB
DSN1
Tbio
Novelty:  0.05336903
p_int:  0.999993254
p_ni:  0.000006742
p_wrong:  4e-9
Score:  0.997
Data Source:  BioPlex,Reactome,STRINGDB
NSL1
Tbio
Novelty:  0.01396984
p_int:  0.99999041
p_ni:  0.00000959
Score:  0.988
Data Source:  BioPlex,Reactome,STRINGDB
TPST2
Tbio
Family:  Enzyme
Novelty:  0.02551048
p_int:  0.999979209
p_ni:  0.000020791
Data Source:  BioPlex
SYCE1
Tbio
Novelty:  0.05038876
p_int:  0.999971851
p_ni:  0.000028149
Data Source:  BioPlex
EXOC1
Tbio
Novelty:  0.01073858
p_int:  0.999936512
p_ni:  0.000063484
p_wrong:  3e-9
Data Source:  BioPlex
ZWINT
Tbio
Novelty:  0.02153276
p_int:  0.999919856
p_ni:  0.000080134
p_wrong:  1e-8
Score:  0.999
Data Source:  BioPlex,STRINGDB
FAM9C
Tdark
Novelty:  0.86727989
p_int:  0.999786148
p_ni:  0.000213839
p_wrong:  1.3e-8
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (18)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (R-HSA-141444)

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Find Similar Targets
Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Reactome
Amplification of signal from the kinetochores
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
Cell Cycle, Mitotic
Name
Explore in Pharos
Explore in Source
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Amplification of signal from the kinetochores
Cell Cycle
Cell Cycle Checkpoints
Cell Cycle, Mitotic
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
2
1
2
52
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
2
52
IDG Resources
No IDG generated resources found
Orthologs (17)
1 – 5 of 17
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NDC80, kinetochore complex component
VGNC:7325
455320
Macaque
NDC80, kinetochore complex component
696232
Mouse
MGI:1914302
67052
Rat
RGD:1310154
301701
Dog
NDC80, kinetochore complex component
VGNC:43670
480190
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NDC80, kinetochore complex component
Macaque
NDC80, kinetochore complex component
Mouse
Rat
Dog
NDC80, kinetochore complex component
Publication Statistics
PubMed Score 289.92
PubMed score by year
PubTator Score 269.23
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title