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Tbio
NCSTN
Nicastrin

Protein Summary
Description
Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed:10993067, PubMed:12679784, PubMed:25043039, PubMed:26280335). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. This gene encodes a type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000294785
  • ENSP00000294785
  • ENSG00000162736

Symbol
  • KIAA0253
  • ATAG1874
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.96
protein complex
0.94
histone modification site profile
0.86
cellular component
0.78
transcription factor perturbation
0.74


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 195.26   (req: < 5)
Gene RIFs: 81   (req: <= 3)
Antibodies: 448   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 195.26   (req: >= 5)
Gene RIFs: 81   (req: > 3)
Antibodies: 448   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (177)
ACTA1
Tbio
Novelty:  0.00111813
p_int:  0.999999871
p_ni:  1.29e-7
Score:  0.177
Data Source:  BioPlex,STRINGDB
ALOX5
Tclin
Family:  Enzyme
Novelty:  0.00062988
p_int:  0.999845316
p_ni:  0.000154684
Score:  0.334
Data Source:  BioPlex,STRINGDB
MICAL1
Tbio
Family:  Enzyme
Novelty:  0.02668048
p_int:  0.994293887
p_ni:  0.005658908
p_wrong:  0.000047205
Score:  0.175
Data Source:  BioPlex,STRINGDB
RRAS
Tbio
Family:  Enzyme
Novelty:  0.00786502
p_int:  0.982687581
p_ni:  0.016975526
p_wrong:  0.000336893
Score:  0.208
Data Source:  BioPlex,STRINGDB
SRC
Tclin
Family:  Kinase
Novelty:  0.00008479
p_int:  0.974903452
p_ni:  0.025094795
p_wrong:  0.000001753
Score:  0.205
Data Source:  BioPlex,STRINGDB
PAG1
Tbio
Novelty:  0.01390911
p_int:  0.945469639
p_ni:  0.05451726
p_wrong:  0.000013101
Data Source:  BioPlex
EEF1A2
Tchem
Novelty:  0.001472
p_int:  0.914109812
p_ni:  0.085890188
Data Source:  BioPlex
EEPD1
Tbio
Family:  Enzyme
Novelty:  0.28148309
p_int:  0.904822289
p_ni:  0.08506369
p_wrong:  0.01011402
Score:  0.179
Data Source:  BioPlex,STRINGDB
PTPRG
Tchem
Family:  Enzyme
Novelty:  0.01920574
p_int:  0.893194732
p_ni:  0.106805267
p_wrong:  1e-9
Score:  0.15
Data Source:  BioPlex,STRINGDB
VASN
Tbio
Novelty:  0.05424159
p_int:  0.883486142
p_ni:  0.116513858
Score:  0.416
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (51)
Activated NOTCH1 Transmits Signal to the Nucleus (R-HSA-2122948)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 37
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated NOTCH1 Transmits Signal to the Nucleus
Reactome
Amyloid fiber formation
Reactome
Axon guidance
Reactome
Cell death signalling via NRAGE, NRIF and NADE
Reactome
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Name
Explore in Pharos
Explore in Source
Activated NOTCH1 Transmits Signal to the Nucleus
Amyloid fiber formation
Axon guidance
Cell death signalling via NRAGE, NRIF and NADE
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (29)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
60.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
60.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nicastrin
VGNC:1344
457435
Macaque
nicastrin
719696
Mouse
MGI:1891700
59287
Rat
RGD:631418
289231
Dog
nicastrin
VGNC:43668
488638
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nicastrin
Macaque
nicastrin
Mouse
Rat
Dog
nicastrin
Publication Statistics
PubMed Score 195.26
PubMed score by year
PubTator Score 84.75
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title