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Tbio
NCR3LG1
Natural cytotoxicity triggering receptor 3 ligand 1

Protein Summary
Description
Triggers NCR3-dependent natural killer cell activation. B7H6 belongs to the B7 family (see MIM 605402) and is selectively expressed on tumor cells. Interaction of B7H6 with NKp30 (NCR3; MIM 611550) results in natural killer (NK) cell activation and cytotoxicity (Brandt et al., 2009 [PubMed 19528259]).[supplied by OMIM, Jan 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338965
  • ENSP00000341637
  • ENSG00000188211
  • ENST00000530403
  • ENSP00000434394

Symbol
  • B7H6
  • B7H6
  • B7-H6
  • DKFZp686O24166
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
microRNA
0.78
tissue
0.77
tissue sample
0.72
cell line
0.48


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.16   (req: < 5)
Gene RIFs: 32   (req: <= 3)
Antibodies: 262   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.16   (req: >= 5)
Gene RIFs: 32   (req: > 3)
Antibodies: 262   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0