NCR3LG1
Natural cytotoxicity triggering receptor 3 ligand 1
Protein Summary
Triggers NCR3-dependent natural killer cell activation. B7H6 belongs to the B7 family (see MIM 605402) and is selectively expressed on tumor cells. Interaction of B7H6 with NKp30 (NCR3; MIM 611550) results in natural killer (NK) cell activation and cytotoxicity (Brandt et al., 2009 [PubMed 19528259]).[supplied by OMIM, Jan 2011]
- ENST00000338965
- ENSP00000341637
- ENSG00000188211
- ENST00000530403
- ENSP00000434394
- B7H6
- B7H6
- B7-H6
- DKFZp686O24166
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.92 | ||
microRNA | 0.78 | ||
tissue | 0.77 | ||
tissue sample | 0.72 | ||
cell line | 0.48 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 64.16 (req: < 5)
Gene RIFs: 34 (req: <= 3)
Antibodies: 262 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 64.16 (req: >= 5)
Gene RIFs: 34 (req: > 3)
Antibodies: 262 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 2
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0