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Tbio
NCR1
Natural cytotoxicity triggering receptor 1

Protein Summary
Description
Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000350790
  • ENSP00000344358
  • ENSG00000189430
  • ENST00000357397
  • ENSP00000349972
  • ENST00000610621
  • ENSP00000483452
  • ENSG00000273535
  • ENST00000610753
  • ENSP00000484377
  • ENST00000611098
  • ENSP00000479222
  • ENSG00000275156
  • ENST00000611105
  • ENSP00000483028
  • ENSG00000278362
  • ENST00000611942
  • ENSP00000483723
  • ENST00000612239
  • ENSP00000481692
  • ENST00000612645
  • ENSP00000481540
  • ENST00000612896
  • ENSP00000484520
  • ENST00000613135
  • ENSP00000480145
  • ENST00000613556
  • ENSP00000482092
  • ENST00000615622
  • ENSP00000478507
  • ENST00000617154
  • ENSP00000481971
  • ENST00000617784
  • ENSP00000482423
  • ENST00000618973
  • ENSP00000483611
  • ENST00000619077
  • ENSP00000484221
  • ENST00000619451
  • ENSP00000482536
  • ENST00000620296
  • ENSP00000484067
  • ENST00000621059
  • ENSP00000484831
  • ENST00000621652
  • ENSP00000477625
  • ENST00000639155
  • ENSP00000491020
  • ENSG00000284113
  • ENST00000640377
  • ENSP00000491933
  • ENSG00000284208
  • ENST00000640753
  • ENSP00000492673
  • ENST00000640987
  • ENSP00000492426

Symbol
  • LY94
  • LY94
  • CD335
  • NKP46
  • NK-p46
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.72
cellular component
0.69
biological term
0.64
tissue
0.61
phenotype
0.58


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 370.8   (req: < 5)
Gene RIFs: 66   (req: <= 3)
Antibodies: 684   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 370.8   (req: >= 5)
Gene RIFs: 66   (req: > 3)
Antibodies: 684   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (227)
CD247
Tbio
Novelty:  0.00217194
Score:  0.937
Data Source:  Reactome,STRINGDB
FCGR1A
Tclin
Novelty:  0.00073204
Score:  0.926
Data Source:  Reactome,STRINGDB
FCER1G
Tbio
Novelty:  0.00783146
Score:  0.921
Data Source:  STRINGDB
KLRK1
Tbio
Novelty:  0.0009209
Score:  0.92
Data Source:  STRINGDB
NCR2
Tbio
Novelty:  0.00685029
Score:  0.92
Data Source:  STRINGDB
NCR3
Tbio
Novelty:  0.00428788
Score:  0.92
Data Source:  STRINGDB
KLRC1
Tbio
Novelty:  0.00312379
Score:  0.868
Data Source:  STRINGDB
KLRD1
Tbio
Novelty:  0.00218019
Score:  0.851
Data Source:  STRINGDB
IL15
Tbio
Novelty:  0.00049351
Score:  0.821
Data Source:  STRINGDB
CD226
Tbio
Novelty:  0.00374102
Score:  0.821
Data Source:  STRINGDB
Pathways (4)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Immune System
Reactome
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Immune System
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (56)
Items per page:
1 – 5 of 56
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
2
3
95
mean platelet volume
3
2
3
95
mean platelet volume
3
2
3
95
mean platelet volume
3
2
3
95
reticulocyte count
4
2
4
91.5
Items per page:
1 – 5 of 56
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
95
mean platelet volume
3
95
mean platelet volume
3
95
mean platelet volume
3
95
reticulocyte count
4
91.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
natural cytotoxicity triggering receptor 1
VGNC:11197
100322885
Macaque
natural cytotoxicity triggering receptor 1
574242
Mouse
MGI:1336212
17086
Rat
RGD:621288
117547
Dog
natural cytotoxicity triggering receptor 1
VGNC:53740
611390
Species
Name
OMA
EggNOG
Inparanoid
Chimp
natural cytotoxicity triggering receptor 1
Macaque
natural cytotoxicity triggering receptor 1
Mouse
Rat
Dog
natural cytotoxicity triggering receptor 1
Publication Statistics
PubMed Score 370.80
PubMed score by year
PubTator Score 175.82
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title