Tchem NCOR1 Nuclear receptor corepressor 1

Protein Summary

Description

Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 17 and 20.[provided by RefSeq, Jun 2010]

Uniprot Accession IDs

• O75376
• B3DLF8
• E9PGV6
• Q86YY0
• Q9UPV5
• Q9UQ18
• N-CoR

Gene Name

• NCOR1

Ensembl ID

• ENST00000268712
• ENSP00000268712
• ENSG00000141027
• ENST00000395848
• ENSP00000379189
• ENST00000395851
• ENSP00000379192

Symbol

• KIAA1047
• N-CoR
• TRAC1
• N-CoR1
• hN-CoR
• PPP1R109

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
hub protein	1
biological process	0.99
molecular function	0.96
kinase perturbation	0.93

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Transcription Cofactor / Nuclear Receptor Corepressor 1

Protein / Nucleic Acid Binding / Nuclear Receptor Corepressor 1

DTO Classes

Protein / Transcription Factor / Transcription Cofactor / Nuclear Receptor Corepressor 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 461.76   (req: < 5)

Gene RIFs: 102   (req: <= 3)

Antibodies: 381   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 461.76   (req: >= 5)

Gene RIFs: 102   (req: > 3)

Antibodies: 381   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2