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Tbio
NCOA6
Nuclear receptor coactivator 6

Protein Summary
Description
Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins. The protein encoded by this gene is a transcriptional coactivator that can interact with nuclear hormone receptors to enhance their transcriptional activator functions. This protein has been shown to be involved in the hormone-dependent coactivation of several receptors, including prostanoid, retinoid, vitamin D3, thyroid ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359003
  • ENSP00000351894
  • ENSG00000198646
  • ENST00000374796
  • ENSP00000363929

Symbol
  • AIB3
  • KIAA0181
  • RAP250
  • TRBP
  • NRC
  • AIB3
  • ASC2
  • PRIP
  • TRBP
  • RAP250
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.98
virus perturbation
0.83
biological process
0.75
molecular function
0.7
phenotype
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 167.86   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 79   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 167.86   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 79   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (186)
WDR5
Tchem
Novelty:  0.0059945
p_int:  0.999991579
p_ni:  3.88e-7
p_wrong:  0.000008033
Score:  0.976
Data Source:  BioPlex,STRINGDB
PAXIP1
Tbio
Novelty:  0.01728724
Score:  0.991
Data Source:  STRINGDB
KMT2C
Tbio
Family:  Epigenetic
Novelty:  0.00689437
Score:  0.987
Data Source:  STRINGDB
KMT2D
Tbio
Family:  Epigenetic
Novelty:  0.00380525
Score:  0.981
Data Source:  STRINGDB
RBBP5
Tbio
Novelty:  0.02221059
Score:  0.98
Data Source:  STRINGDB
ASH2L
Tbio
Family:  Enzyme
Novelty:  0.01586766
Score:  0.98
Data Source:  STRINGDB
KDM6A
Tchem
Family:  Epigenetic
Novelty:  0.00267001
Score:  0.979
Data Source:  STRINGDB
EP300
Tchem
Family:  Epigenetic
Novelty:  0.00055009
Score:  0.977
Data Source:  STRINGDB
TGS1
Tbio
Family:  Enzyme
Novelty:  0.03390504
Score:  0.977
Data Source:  STRINGDB
MED1
Tbio
Family:  Enzyme
Novelty:  0.00852082
Score:  0.97
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (23)
Activation of HOX genes during differentiation (R-HSA-5619507)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 17
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of HOX genes during differentiation
Reactome
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Reactome
Activation of gene expression by SREBF (SREBP)
Reactome
BMAL1:CLOCK,NPAS2 activates circadian gene expression
Reactome
Circadian Clock
Name
Explore in Pharos
Explore in Source
Activation of HOX genes during differentiation
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Activation of gene expression by SREBF (SREBP)
BMAL1:CLOCK,NPAS2 activates circadian gene expression
Circadian Clock
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (27)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (25)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
6
5
6
97.8
3
2
0
1.8
97.5
suntan
1
2
2
96.3
creatinine measurement
4
4
4
93.6
appendicular lean mass
2
6
6
91.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
6
97.8
0
1.8
97.5
suntan
2
96.3
creatinine measurement
4
93.6
appendicular lean mass
6
91.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nuclear receptor coactivator 6
VGNC:6206
469923
Macaque
nuclear receptor coactivator 6 [Source:HGNC Symbol;Acc:HGNC:15936]
Mouse
MGI:1929915
56406
Rat
RGD:620111
116464
Dog
nuclear receptor coactivator 6
VGNC:43663
477202
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nuclear receptor coactivator 6
Macaque
nuclear receptor coactivator 6 [Source:HGNC Symbol;Acc:HGNC:15936]
Mouse
Rat
Dog
nuclear receptor coactivator 6
Publication Statistics
PubMed Score 167.86
PubMed score by year
PubTator Score 238.92
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title