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Tbio
NCOA5
Nuclear receptor coactivator 5

Protein Summary
Description
Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2). This gene encodes a coregulator for the alpha and beta estrogen receptors and the orphan nuclear receptor NR1D2. The protein localizes to the nucleus, and is thought to have both coactivator and corepressor functions. Its interaction with nuclear receptors is independent of the AF2 domain on the receptors, which is known to regulate interaction with other coreceptors. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000290231
  • ENSP00000290231
  • ENSG00000124160

Symbol
  • KIAA1637
  • CIA
  • bA465L10.6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.9
ligand (protein) perturbation
0.83
virus perturbation
0.83
interacting protein
0.63
cell type or tissue
0.62


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.31   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 119   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.31   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 119   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (85)
NUDT12
Tbio
Family:  Enzyme
Novelty:  0.18740719
p_int:  0.999989816
p_ni:  0.000010184
Score:  0.219
Data Source:  BioPlex,STRINGDB
HTATIP2
Tbio
Family:  Enzyme
Novelty:  0.01940704
p_int:  0.999820956
p_ni:  0.000179044
Score:  0.561
Data Source:  BioPlex,STRINGDB
RBMX
Tbio
Novelty:  0.01705784
p_int:  0.994306071
p_ni:  0.005693738
p_wrong:  1.92e-7
Score:  0.381
Data Source:  BioPlex,STRINGDB
LARP4B
Tbio
Novelty:  0.11363794
p_int:  0.994037623
p_ni:  0.005962219
p_wrong:  1.59e-7
Data Source:  BioPlex
GALC
Tbio
Family:  Enzyme
Novelty:  0.00203532
p_int:  0.99225957
p_ni:  0.00774043
Score:  0.278
Data Source:  BioPlex,STRINGDB
EIF4B
Tbio
Novelty:  0.00665561
p_int:  0.982891694
p_ni:  0.017078213
p_wrong:  0.000030093
Score:  0.181
Data Source:  BioPlex,STRINGDB
CLK2
Tchem
Family:  Kinase
Novelty:  0.13068449
p_int:  0.981163733
p_ni:  0.018836267
Score:  0.155
Data Source:  BioPlex,STRINGDB
LRRC4C
Tbio
Novelty:  0.06534005
p_int:  0.969683417
p_ni:  0.030316583
Score:  0.181
Data Source:  BioPlex,STRINGDB
RPS16
Tbio
Novelty:  0.00261983
p_int:  0.935541151
p_ni:  0.059035009
p_wrong:  0.00542384
Data Source:  BioPlex
SFPQ
Tbio
Novelty:  0.01207637
p_int:  0.857398181
p_ni:  0.142574842
p_wrong:  0.000026977
Score:  0.27
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (7)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (44)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
tumor necrosis factor, receptor superfamily, member 5 measurement
1
2
2
96.1
high density lipoprotein cholesterol measurement
3
3
3
93.3
alkaline phosphatase measurement
1
2
2
89
6
3
3
1.1
85.8
4
3
0
1.1
84.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
tumor necrosis factor, receptor superfamily, member 5 measurement
2
96.1
high density lipoprotein cholesterol measurement
3
93.3
alkaline phosphatase measurement
2
89
3
1.1
85.8
0
1.1
84.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nuclear receptor coactivator 5
VGNC:6205
458296
Macaque
nuclear receptor coactivator 5
717054
Mouse
MGI:2385165
228869
Rat
RGD:1307702
296372
Dog
nuclear receptor coactivator 5
VGNC:43662
477250
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nuclear receptor coactivator 5
Macaque
nuclear receptor coactivator 5
Mouse
Rat
Dog
nuclear receptor coactivator 5
Publication Statistics
PubMed Score 18.31
PubMed score by year
PubTator Score 220.01
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title