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Tbio
NCOA4
Nuclear receptor coactivator 4

Protein Summary
Description
Enhances the androgen receptor transcriptional activity in prostate cancer cells. Ligand-independent coactivator of the peroxisome proliferator-activated receptor (PPAR) gamma. This gene encodes an androgen receptor coactivator. The encoded protein interacts with the androgen receptor in a ligand-dependent manner to enhance its transcriptional activity. Chromosomal translocations between this gene and the ret tyrosine kinase gene, also located on chromosome 10, have been associated with papillary thyroid carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes are present on chromosomes 4, 5, 10, and 14. [provided by RefSeq, Feb 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000578454
  • ENSP00000463027
  • ENSG00000266412
  • ENST00000579039
  • ENSP00000463455
  • ENST00000581486
  • ENSP00000462943
  • ENST00000583565
  • ENSP00000463476
  • ENST00000585132
  • ENSP00000464054

Symbol
  • ARA70
  • ELE1
  • RFG
  • RFG
  • ELE1
  • PTC3
  • ARA70
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.97
disease perturbation
0.9
transcription factor binding site profile
0.89
transcription factor perturbation
0.74
transcription factor
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 200.34   (req: < 5)
Gene RIFs: 31   (req: <= 3)
Antibodies: 345   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 200.34   (req: >= 5)
Gene RIFs: 31   (req: > 3)
Antibodies: 345   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (70)
GMCL1
Tbio
Novelty:  0.1543762
p_int:  0.999803746
p_ni:  0.00019473
p_wrong:  0.000001524
Score:  0.183
Data Source:  BioPlex,STRINGDB
RNF10
Tbio
Novelty:  0.09086567
p_int:  0.999637984
p_ni:  0.00013658
p_wrong:  0.000225436
Data Source:  BioPlex
PRELID2
Tdark
Novelty:  0.38276284
p_int:  0.999404899
p_ni:  0.000204141
p_wrong:  0.00039096
Data Source:  BioPlex
HERC2
Tbio
Family:  Enzyme
Novelty:  0.06552683
p_int:  0.999383791
p_ni:  0.000616209
Score:  0.506
Data Source:  BioPlex,STRINGDB
NEURL4
Tdark
Novelty:  0.20430708
p_int:  0.998118432
p_ni:  0.001881568
Score:  0.298
Data Source:  BioPlex,STRINGDB
FTH1
Tbio
Novelty:  0.000863
p_int:  0.98956274
p_ni:  0.01043726
Score:  0.952
Data Source:  BioPlex,STRINGDB
FTL
Tbio
Novelty:  0.00235168
p_int:  0.981822336
p_ni:  0.01817764
p_wrong:  2.5e-8
Score:  0.957
Data Source:  BioPlex,STRINGDB
AR
Tclin
Family:  NR
Novelty:  0.00013531
Score:  0.998
Data Source:  STRINGDB
RET
Tclin
Family:  Kinase
Novelty:  0.00028324
Score:  0.966
Data Source:  STRINGDB
CCDC6
Tbio
Novelty:  0.00702098
Score:  0.944
Data Source:  STRINGDB
Nearest Tclin Targets (4)
Explore Nearest Tclin Targets
1 – 4 of 4
PIK3CA
Tclin
Family:  Kinase
KEGG Distance:  2
Common Pathways:  1
RAF1
Tclin
Family:  Kinase
KEGG Distance:  2
Common Pathways:  1
BRAF
Tclin
Family:  Kinase
KEGG Distance:  2
Common Pathways:  2
PIK3CD
Tclin
Family:  Kinase
KEGG Distance:  2
Common Pathways:  1
Pathways (8)
Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Ferroptosis
KEGG
Pathways in cancer
KEGG
Thyroid cancer
Name
Explore in Pharos
Explore in Source
Ferroptosis
Pathways in cancer
Thyroid cancer
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
4
3
4
95.2
mean corpuscular hemoglobin concentration
2
2
2
93.9
mean corpuscular hemoglobin
3
3
3
93.8
14
2
1
1.2
89.7
red blood cell density measurement
2
2
2
89.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
4
95.2
mean corpuscular hemoglobin concentration
2
93.9
mean corpuscular hemoglobin
3
93.8
1
1.2
89.7
red blood cell density measurement
2
89.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
nuclear receptor coactivator 4
709509
Mouse
MGI:1350932
27057
Rat
RGD:1563014
619385
Dog
nuclear receptor coactivator 4
VGNC:43661
477750
Horse
nuclear receptor coactivator 4
VGNC:20598
100062485
Species
Name
OMA
EggNOG
Inparanoid
Macaque
nuclear receptor coactivator 4
Mouse
Rat
Dog
nuclear receptor coactivator 4
Horse
nuclear receptor coactivator 4
Publication Statistics
PubMed Score 200.34
PubMed score by year
PubTator Score 152.74
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title