Tchem NCOA3 Nuclear receptor coactivator 3

Protein Summary

Description

Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit. The protein encoded by this gene is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. Several transcript variants encoding different isoforms have been found for this gene. In addition, a polymorphic repeat region is found in the C-terminus of the encoded protein. [provided by RefSeq, Mar 2010]

Uniprot Accession IDs

• Q9Y6Q9
• A4LAZ5
• Q0VF45
• Q5JYD9
• Q5JYE0
• Q9BR49
• Q9UPC9
• Q9UPG4
• Q9UPG7
• NCoA-3

Gene Name

• NCOA3

Ensembl ID

• ENST00000371997
• ENSP00000361065
• ENSG00000124151
• ENST00000371998
• ENSP00000361066
• ENST00000372004
• ENSP00000361073

Symbol

• AIB1
• BHLHE42
• RAC3
• TRAM1
• ACTR
• AIB1
• RAC3
• SRC3
• pCIP
• AIB-1
• CTG26
• SRC-3
• CAGH16
• KAT13B
• TNRC14
• TNRC16
• TRAM-1
• bHLHe42

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	1
protein domain	1
kinase	0.98
transcription factor binding site profile	0.96
molecular function	0.94

Protein Classes

PANTHER Classes

Protein / Transferase / Acetyltransferase / Nuclear Receptor Coactivator 3

Protein / Transcription Factor / Nuclear Receptor Coactivator 3

DTO Classes

Protein / Kinase / Protein Kinase / Tk Group / Src Family / Nuclear Receptor Coactivator 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 661.83   (req: < 5)

Gene RIFs: 183   (req: <= 3)

Antibodies: 541   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 661.83   (req: >= 5)

Gene RIFs: 183   (req: > 3)

Antibodies: 541   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 10

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2