NCOA3
Nuclear receptor coactivator 3
Protein Summary
Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit. The protein encoded by this gene is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. This protein is initially found in the cytoplasm but is transl ...more
- ENST00000371997
- ENSP00000361065
- ENSG00000124151
- ENST00000371998
- ENSP00000361066
- ENST00000372004
- ENSP00000361073
- AIB1
- BHLHE42
- RAC3
- TRAM1
- ACTR
- AIB1
- RAC3
- SRC3
- pCIP
- AIB-1
- CTG26
- SRC-3
- CAGH16
- KAT13B
- TNRC14
- TNRC16
- TRAM-1
- bHLHe42
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
hub protein | 1 | ||
protein domain | 1 | ||
kinase | 0.98 | ||
transcription factor binding site profile | 0.96 | ||
molecular function | 0.94 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 604.57 (req: < 5)
Gene RIFs: 183 (req: <= 3)
Antibodies: 541 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 604.57 (req: >= 5)
Gene RIFs: 183 (req: > 3)
Antibodies: 541 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 24
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 10
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 2
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (2)
Active Ligands (10)
Protein-Protein Interactions (337)
Nearest Tclin Targets
Pathways (32)
Reactome (14)
KEGG (5)
PathwayCommons (7)
WikiPathways (6)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Activation of HOX genes during differentiation | ||||
Reactome | Activation of anterior HOX genes in hindbrain development during early embryogenesis | ||||
Reactome | Developmental Biology | ||||
Reactome | ESR-mediated signaling | ||||
Reactome | Estrogen-dependent gene expression | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Activation of HOX genes during differentiation | ||||
Activation of anterior HOX genes in hindbrain development during early embryogenesis | ||||
Developmental Biology | ||||
ESR-mediated signaling | ||||
Estrogen-dependent gene expression | ||||
Viral Interactions (0)
Gene Ontology Terms (31)
Functions (12)
Components (7)
Processes (12)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | CAFA | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | CAFA | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence Alignment (ISA) | NTNU_SB | |||
Disease Associations (null)
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
high density lipoprotein cholesterol measurement | 3 | 5 | 6 | 94 | |||||
apolipoprotein A 1 measurement | 2 | 5 | 5 | 93.4 | |||||
balding measurement | 1 | 1 | 1 | 49.5 | |||||
snoring measurement | 1 | 1 | 0 | 1 | 24.5 | ||||
1 | 1 | 0 | 1.3 | 7.9 | |||||
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
high density lipoprotein cholesterol measurement | 6 | 94 | |||||
apolipoprotein A 1 measurement | 5 | 93.4 | |||||
balding measurement | 1 | 49.5 | |||||
snoring measurement | 0 | 1 | 24.5 | ||||
0 | 1.3 | 7.9 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | nuclear receptor coactivator 3 | VGNC:6203 | 458308 | |||||
Macaque | nuclear receptor coactivator 3 | 705431 | ||||||
Mouse | MGI:1276535 | 17979 | ||||||
Rat | RGD:620109 | 84584 | ||||||
Dog | nuclear receptor coactivator 3 | VGNC:54658 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | nuclear receptor coactivator 3 | |||||
Macaque | nuclear receptor coactivator 3 | |||||
Mouse | ||||||
Rat | ||||||
Dog | nuclear receptor coactivator 3 | |||||
Publication Statistics
PubMed Score 604.57
PubMed score by year
PubTator Score 292.94
PubTator score by year
Related Publications
Text Mined References (263)
GeneRif Annotations (183)
Items per page:
0 of 0
PMID | Year | Title |
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