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Tbio
NCKIPSD
NCK-interacting protein with SH3 domain

Protein Summary
Description
Has an important role in stress fiber formation induced by active diaphanous protein homolog 1 (DRF1). Induces microspike formation, in vivo (By similarity). In vitro, stimulates N-WASP-induced ARP2/3 complex activation in the absence of CDC42 (By similarity). May play an important role in the maintenance of sarcomeres and/or in the assembly of myofibrils into sarcomeres. Implicated in regulation of actin polymerization and cell adhesion. Plays a role in angiogenesis. The protein encoded by this gene is localized exclusively in the cell nucleus. It plays a role in signal transduction, and may function in the maintenance of sarcomeres and in the assembly of myofibrils into sarcomeres. It also plays an important role in stress fiber formation. The gene is involved in therapy-related leukemia by a chromosomal translocation t(3;11)(p21;q23) that involves this gene and the myeloid/lymphoid leukemia gene. Alternative splicing results in multiple transcript variants of this gene. [provided by ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000294129
  • ENSP00000294129
  • ENSG00000213672
  • ENST00000416649
  • ENSP00000389059

Symbol
  • AF3P21
  • SPIN90
  • DIP
  • DIP1
  • ORF1
  • WISH
  • VIP54
  • AF3P21
  • SPIN90
  • WASLBP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
histone modification site profile
0.74
hub protein
0.71
virus
0.66
transcription factor binding site profile
0.65


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.67   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 121   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.67   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 121   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (93)
FCHSD1
Tdark
Novelty:  0.53501769
p_int:  0.999999965
p_ni:  3e-8
p_wrong:  5e-9
Score:  0.5
Data Source:  BioPlex,STRINGDB
ITSN2
Tbio
Novelty:  0.03036854
p_int:  0.999999846
p_ni:  1.53e-7
p_wrong:  1e-9
Score:  0.257
Data Source:  BioPlex,STRINGDB
PALLD
Tbio
Novelty:  0.01191944
p_int:  0.999999357
p_ni:  6.43e-7
Score:  0.695
Data Source:  BioPlex,STRINGDB
GAS7
Tbio
Novelty:  0.02561257
p_int:  0.9999988
p_wrong:  0.000001199
Score:  0.427
Data Source:  BioPlex,STRINGDB
ARHGEF6
Tbio
Novelty:  0.02162737
p_int:  0.999996892
p_ni:  0.000003106
p_wrong:  1e-9
Score:  0.744
Data Source:  BioPlex,STRINGDB
NCK1
Tbio
Novelty:  0.00352084
p_int:  0.999992378
p_ni:  0.000007129
p_wrong:  4.93e-7
Score:  0.971
Data Source:  BioPlex,STRINGDB
GIT1
Tbio
Family:  Enzyme
Novelty:  0.01022741
p_int:  0.999985358
p_ni:  0.000014642
Score:  0.607
Data Source:  BioPlex,STRINGDB
GIT2
Tbio
Family:  Enzyme
Novelty:  0.01530665
p_int:  0.999979184
p_ni:  0.000020816
Score:  0.785
Data Source:  BioPlex,STRINGDB
ARHGEF7
Tbio
Novelty:  0.00919946
p_int:  0.99997692
p_ni:  0.00002308
Score:  0.845
Data Source:  BioPlex,STRINGDB
ZFYVE9
Tbio
Novelty:  0.00565862
p_int:  0.999945448
p_ni:  0.000054544
p_wrong:  8e-9
Score:  0.173
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Fcgamma receptor (FCGR) dependent phagocytosis (R-HSA-2029480)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Fcgamma receptor (FCGR) dependent phagocytosis
Reactome
Immune System
Reactome
Innate Immune System
Reactome
RHO GTPase Effectors
Reactome
RHO GTPases Activate WASPs and WAVEs
Name
Explore in Pharos
Explore in Source
Fcgamma receptor (FCGR) dependent phagocytosis
Immune System
Innate Immune System
RHO GTPase Effectors
RHO GTPases Activate WASPs and WAVEs
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (32)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
2
5
5
89.5
heel bone mineral density
2
2
2
84.8
self reported educational attainment
4
5
4
5.9
84.4
macrophage inflammatory protein 1b measurement
1
2
2
82.4
waist-hip ratio
2
3
3
80.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
5
89.5
heel bone mineral density
2
84.8
self reported educational attainment
4
5.9
84.4
macrophage inflammatory protein 1b measurement
2
82.4
waist-hip ratio
3
80.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NCK interacting protein with SH3 domain
VGNC:2439
460351
Macaque
NCK interacting protein with SH3 domain
709410
Mouse
MGI:1931834
80987
Rat
RGD:1311323
301009
Dog
NCK interacting protein with SH3 domain
VGNC:43656
484776
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NCK interacting protein with SH3 domain
Macaque
NCK interacting protein with SH3 domain
Mouse
Rat
Dog
NCK interacting protein with SH3 domain
Publication Statistics
PubMed Score 21.67
PubMed score by year
PubTator Score 276.26
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title