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Tbio
NCKAP1
Nck-associated protein 1

Protein Summary
Description
Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360982
  • ENSP00000354251
  • ENSG00000061676
  • ENST00000361354
  • ENSP00000355348

Symbol
  • HEM2
  • KIAA0587
  • NAP1
  • HEM2
  • NAP1
  • NAP125
  • p125Nap1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
gene perturbation
0.95
biological process
0.9
transcription factor perturbation
0.84
interacting protein
0.83


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.95   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 183   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.95   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 183   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (137)
NHSL1
Tdark
Novelty:  0.28557146
p_int:  0.999999994
p_ni:  6e-9
p_wrong:  1e-9
Score:  0.299
Data Source:  BioPlex,STRINGDB
WASF1
Tbio
Novelty:  0.00977488
p_int:  0.999999992
p_ni:  8e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
ABI1
Tbio
Novelty:  0.00796638
p_int:  0.999999941
p_ni:  6e-8
Score:  0.998
Data Source:  BioPlex,STRINGDB
ABI2
Tbio
Novelty:  0.02324355
p_int:  0.999999908
p_ni:  9.2e-8
Score:  0.995
Data Source:  BioPlex,STRINGDB
KIAA1522
Tdark
Novelty:  0.15028395
p_int:  0.999999648
p_ni:  3.52e-7
Data Source:  BioPlex
WASF2
Tbio
Novelty:  0.00968798
p_int:  0.999999203
p_ni:  7.97e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
CYFIP2
Tbio
Novelty:  0.01910939
p_int:  0.999998888
p_ni:  0.000001112
Score:  0.999
Data Source:  BioPlex,STRINGDB
BRK1
Tbio
Novelty:  0.02289534
p_int:  0.999998212
p_ni:  0.000001781
p_wrong:  6e-9
Score:  0.998
Data Source:  BioPlex,STRINGDB
AMZ1
Tdark
Family:  Enzyme
Novelty:  0.246305
p_int:  0.999997996
p_ni:  0.000002004
Score:  0.329
Data Source:  BioPlex,STRINGDB
NCK2
Tbio
Novelty:  0.02220251
p_int:  0.999988022
p_ni:  0.000011978
Score:  0.667
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (19)
Fcgamma receptor (FCGR) dependent phagocytosis (R-HSA-2029480)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Fcgamma receptor (FCGR) dependent phagocytosis
Reactome
Immune System
Reactome
Innate Immune System
Reactome
RHO GTPase Effectors
Reactome
RHO GTPases Activate WASPs and WAVEs
Name
Explore in Pharos
Explore in Source
Fcgamma receptor (FCGR) dependent phagocytosis
Immune System
Innate Immune System
RHO GTPase Effectors
RHO GTPases Activate WASPs and WAVEs
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
1
3
70.9
self reported educational attainment
1
1
1
5.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
70.9
self reported educational attainment
1
5.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NCK associated protein 1
VGNC:2059
459801
Macaque
NCK associated protein 1
711124
Mouse
MGI:1355333
50884
Rat
RGD:61939
58823
Dog
NCK associated protein 1
VGNC:43653
478828
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NCK associated protein 1
Macaque
NCK associated protein 1
Mouse
Rat
Dog
NCK associated protein 1
Publication Statistics
PubMed Score 29.95
PubMed score by year
PubTator Score 11.56
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title