Tbio NCF4 Neutrophil cytosol factor 4

Protein Summary

Description

Component of the NADPH-oxidase, a multicomponent enzyme system responsible for the oxidative burst in which electrons are transported from NADPH to molecular oxygen, generating reactive oxidant intermediates. It may be important for the assembly and/or activation of the NADPH-oxidase complex. The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q15080
• A8K4F9
• O60808
• Q86U56
• Q9BU98
• Q9NP45
• NCF-4

Gene Name

• NCF4

Ensembl ID

• ENST00000248899
• ENSP00000248899
• ENSG00000100365
• ENST00000397147
• ENSP00000380334

Symbol

• SH3PXD4
• NCF
• CGD3
• P40PHOX
• SH3PXD4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.72
virus perturbation	0.72
kinase perturbation	0.6
protein domain	0.58
tissue sample	0.58

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 187.35   (req: < 5)

Gene RIFs: 37   (req: <= 3)

Antibodies: 458   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 187.35   (req: >= 5)

Gene RIFs: 37   (req: > 3)

Antibodies: 458   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0