Tbio NCF1 Neutrophil cytosol factor 1

Protein Summary

Description

NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production). The protein encoded by this gene is a 47 kDa cytosolic subunit of neutrophil NADPH oxidase. This oxidase is a multicomponent enzyme that is activated to produce superoxide anion. Mutations in this gene have been associated with chronic granulomatous disease. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P14598
• A6NEH2
• A8K7S9
• O43842
• Q2PP07
• Q53FR5
• Q9BU90
• Q9BXI7
• Q9BXI8
• Q9UDV9
• Q9UMU2
• NCF-1

Gene Name

• NCF1

Ensembl ID

• ENST00000289473
• ENSP00000289473
• ENSG00000158517

Symbol

• NOXO2
• SH3PXD1A
• NCF1A
• NOXO2
• p47phox
• SH3PXD1A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase	1
chemical	0.97
hub protein	0.97
biological process	0.85
biological term	0.78

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 911.79   (req: < 5)

Gene RIFs: 100   (req: <= 3)

Antibodies: 850   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 911.79   (req: >= 5)

Gene RIFs: 100   (req: > 3)

Antibodies: 850   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0