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Tbio
NCBP3
Nuclear cap-binding protein subunit 3

Protein Summary
Description
Associates with NCBP1/CBP80 to form an alternative cap-binding complex (CBC) which plays a key role in mRNA export. NCBP3 serves as adapter protein linking the capped RNAs (m7GpppG-capped RNA) to NCBP1/CBP80. Unlike the conventional CBC with NCBP2 which binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus, the alternative CBC with NCBP3 does not bind snRNA and associates only with mRNA thereby playing a role in only mRNA export. The alternative CBC is particularly important in cellular stress situations such as virus infections and the NCBP3 activity is critical to inhibit virus growth (PubMed:26382858).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000389005
  • ENSP00000373657
  • ENSG00000074356

Symbol
  • C17orf85
  • ELG
  • C17orf85
  • HSA277841
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.86   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 34   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.86   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 34   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (73)
LARP4B
Tbio
Novelty:  0.11363794
p_int:  0.999219104
p_ni:  0.000780896
Data Source:  BioPlex
LUC7L2
Tdark
Novelty:  0.36989457
p_int:  0.998930669
p_ni:  0.001069331
Score:  0.212
Data Source:  BioPlex,STRINGDB
CCDC9
Tdark
Novelty:  0.73149492
p_int:  0.998872049
p_ni:  0.001127939
p_wrong:  1.2e-8
Data Source:  BioPlex
PRPF40A
Tbio
Novelty:  0.00898047
p_int:  0.998866846
p_ni:  0.001133154
Score:  0.353
Data Source:  BioPlex,STRINGDB
PNN
Tbio
Novelty:  0.01395394
p_int:  0.998755801
p_ni:  0.001244199
Score:  0.68
Data Source:  BioPlex,STRINGDB
CHTOP
Tbio
Novelty:  0.04170391
p_int:  0.998166937
p_ni:  0.001833063
Score:  0.598
Data Source:  BioPlex,STRINGDB
GSPT2
Tchem
Family:  Enzyme
Novelty:  0.08140512
p_int:  0.99809148
p_ni:  0.00190852
Score:  0.256
Data Source:  BioPlex,STRINGDB
SNIP1
Tbio
Novelty:  0.01865867
p_int:  0.994720584
p_ni:  0.005279416
Score:  0.583
Data Source:  BioPlex,STRINGDB
WSB2
Tbio
Novelty:  0.03939755
p_int:  0.991595495
p_ni:  0.008404505
Score:  0.663
Data Source:  BioPlex,STRINGDB
ELAVL2
Tbio
Novelty:  0.00370708
p_int:  0.975949265
p_ni:  0.024050734
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
2
2
73.4
platelet count
1
1
1
56.2
monocyte percentage of leukocytes
1
1
1
30.2
platelet crit
1
1
1
29
Herpes simplex virus 2 seropositivity
1
1
1
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
73.4
platelet count
1
56.2
monocyte percentage of leukocytes
1
30.2
platelet crit
1
29
Herpes simplex virus 2 seropositivity
1
24.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nuclear cap binding subunit 3
VGNC:9453
454436
Mouse
MGI:1914124
66874
Rat
RGD:1308139
360563
Dog
nuclear cap binding subunit 3
VGNC:43647
611456
Horse
nuclear cap binding subunit 3
VGNC:20583
100072681
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nuclear cap binding subunit 3
Mouse
Rat
Dog
nuclear cap binding subunit 3
Horse
nuclear cap binding subunit 3
Publication Statistics
PubMed Score 14.86
PubMed score by year
PubTator Score 8.60
PubTator score by year
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Related Publications
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PMID
Year
Title