You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
NCBP1
Nuclear cap-binding protein subunit 1

Protein Summary
Description
Component of the cap-binding complex (CBC), which binds cotranscriptionally to the 5'-cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus via its interaction with ALYREF/THOC4/ALY, leading to the recruitment of the mRNA export machinery to the 5'-end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC comp ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375147
  • ENSP00000364289
  • ENSG00000136937

Symbol
  • CBP80
  • NCBP
  • NCBP
  • Sto1
  • CBP80
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.92
disease perturbation
0.9
transcription factor perturbation
0.88
virus perturbation
0.88
protein domain
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.44   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 211   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.44   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 211   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (623)
SNIP1
Tbio
Novelty:  0.01865867
p_int:  0.934654675
p_ni:  0.065345325
Score:  0.707
Data Source:  BioPlex,STRINGDB
GSPT2
Tchem
Family:  Enzyme
Novelty:  0.08140512
p_int:  0.913217857
p_ni:  0.086782143
Score:  0.95
Data Source:  BioPlex,STRINGDB
NKAPD1
Tdark
Novelty:  1.56979675
p_int:  0.86574168
p_ni:  0.13425832
Data Source:  BioPlex
SNRNP70
Tbio
Novelty:  0.00116631
p_int:  0.864528932
p_ni:  0.135471068
Score:  0.972
Data Source:  BioPlex,STRINGDB
LARP4B
Tbio
Novelty:  0.11363794
p_int:  0.842074606
p_ni:  0.157925394
Data Source:  BioPlex
LUC7L
Tbio
Novelty:  0.05748021
p_int:  0.824902355
p_ni:  0.175097645
Score:  0.506
Data Source:  BioPlex,STRINGDB
THOC2
Tbio
Novelty:  0.02886456
Score:  0.999
Data Source:  STRINGDB
NCBP2
Tbio
Novelty:  0.01426734
Score:  0.999
Data Source:  Reactome,STRINGDB
NELFE
Tbio
Novelty:  0.02136256
Score:  0.999
Data Source:  Reactome,STRINGDB
THOC5
Tbio
Novelty:  0.04618391
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (60)
Abortive elongation of HIV-1 transcript in the absence of Tat (R-HSA-167242)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 56
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Abortive elongation of HIV-1 transcript in the absence of Tat
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
Disease
Reactome
Diseases of signal transduction
Name
Explore in Pharos
Explore in Source
Abortive elongation of HIV-1 transcript in the absence of Tat
Axon guidance
Developmental Biology
Disease
Diseases of signal transduction
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
thyroid carcinoma
1
1
0
1.8
78.5
3
2
1
1.1
43.9
sex hormone-binding globulin measurement
2
2
2
39.4
1
1
0
1.1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
thyroid carcinoma
0
1.8
78.5
1
1.1
43.9
sex hormone-binding globulin measurement
2
39.4
0
1.1
21.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nuclear cap binding protein subunit 1
VGNC:4797
464601
Macaque
nuclear cap binding protein subunit 1
718256
Mouse
MGI:1891840
433702
Rat
RGD:1308973
298075
Dog
nuclear cap binding protein subunit 1
VGNC:43645
474772
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nuclear cap binding protein subunit 1
Macaque
nuclear cap binding protein subunit 1
Mouse
Rat
Dog
nuclear cap binding protein subunit 1
Publication Statistics
PubMed Score 74.44
PubMed score by year
PubTator Score 48.43
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title