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Tbio
NCAPH2
Condensin-2 complex subunit H2

Protein Summary
Description
Regulatory subunit of the condensin-2 complex, a complex that seems to provide chromosomes with an additional level of organization and rigidity and in establishing mitotic chromosome architecture (PubMed:14532007). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of chromatin bridges at anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (By similarity). Seems to have lineage-specific role in T-cell development (PubMed:14532007). This gene encodes one of the non-SMC subunits of the condensin II complex. This complex plays an essential role in mitotic chromosome assembly. Alternate splicing o ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000299821
  • ENSP00000299821
  • ENSG00000025770
  • ENST00000395698
  • ENSP00000379050
  • ENST00000420993
  • ENSP00000410088

Symbol
  • CAPH2
  • CAPH2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.98
disease perturbation
0.96
histone modification site profile
0.89
transcription factor perturbation
0.84
small molecule perturbation
0.73


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.99   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 119   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.99   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 119   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (170)
MIS18BP1
Tbio
Novelty:  0.05688807
p_int:  0.999993982
p_ni:  0.000006018
Score:  0.516
Data Source:  BioPlex,STRINGDB
SATB2
Tbio
Family:  TF
Novelty:  0.00405935
p_int:  0.999993552
p_ni:  0.000006448
Data Source:  BioPlex
KIAA0586
Tbio
Novelty:  0.0346398
p_int:  0.99998089
p_ni:  0.0000191
p_wrong:  1e-8
Data Source:  BioPlex
EXPH5
Tbio
Novelty:  0.07504682
p_int:  0.999971361
p_ni:  0.000027553
p_wrong:  0.000001086
Data Source:  BioPlex
SMC2
Tchem
Novelty:  0.06898543
p_int:  0.999832518
p_ni:  0.000167482
Score:  0.998
Data Source:  BioPlex,STRINGDB
ZNF318
Tbio
Novelty:  0.03072403
p_int:  0.999665515
p_ni:  0.000334483
p_wrong:  2e-9
Data Source:  BioPlex
FIGNL1
Tbio
Family:  Enzyme
Novelty:  0.10817841
p_int:  0.999615839
p_ni:  0.00038415
p_wrong:  1.1e-8
Data Source:  BioPlex
EPHA1
Tchem
Family:  Kinase
Novelty:  0.00136672
p_int:  0.999590048
p_ni:  0.000409951
p_wrong:  1e-9
Data Source:  BioPlex
DUS3L
Tdark
Family:  Enzyme
Novelty:  0.24952542
p_int:  0.999576813
p_ni:  0.000399643
p_wrong:  0.000023544
Score:  0.162
Data Source:  BioPlex,STRINGDB
SMC4
Tbio
Novelty:  0.01529151
p_int:  0.999248826
p_ni:  0.000751174
Score:  0.997
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Condensation of Prophase Chromosomes
Reactome
M Phase
Reactome
Mitotic Prophase
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
Condensation of Prophase Chromosomes
M Phase
Mitotic Prophase
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations ()
No disease associations found
GWAS Traits (23)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
5
7
8
99
mean reticulocyte volume
1
4
4
97.6
red blood cell distribution width
4
4
4
95.6
mean corpuscular hemoglobin
3
3
3
94.6
mean corpuscular hemoglobin concentration
2
2
2
91.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
8
99
mean reticulocyte volume
4
97.6
red blood cell distribution width
4
95.6
mean corpuscular hemoglobin
3
94.6
mean corpuscular hemoglobin concentration
2
91.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
non-SMC condensin II complex subunit H2
VGNC:5285
458939
Macaque
non-SMC condensin II complex subunit H2
716120
Mouse
MGI:1289164
52683
Rat
RGD:1565937
300149
Dog
non-SMC condensin II complex subunit H2
VGNC:43644
474458
Species
Name
OMA
EggNOG
Inparanoid
Chimp
non-SMC condensin II complex subunit H2
Macaque
non-SMC condensin II complex subunit H2
Mouse
Rat
Dog
non-SMC condensin II complex subunit H2
Publication Statistics
PubMed Score 11.99
PubMed score by year
PubTator Score 8.18
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title