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Tbio
NCAPG
Condensin complex subunit 3

Protein Summary
Description
Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. This gene encodes a subunit of the condensin complex, which is responsible for the condensation and stabilization of chromosomes during mitosis and meiosis. Phosphorylation of the encoded protein activates the condensin complex. There are pseudogenes for this gene on chromosomes 8 and 15. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000251496
  • ENSP00000251496
  • ENSG00000109805

Symbol
  • CAPG
  • NYMEL3
  • CAPG
  • CHCG
  • YCG1
  • NY-MEL-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.88
cellular component
0.73
histone modification site profile
0.73
interacting protein
0.7
microRNA
0.7


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 103.23   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 169   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 103.23   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 169   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (303)
ARPC1A
Tbio
Novelty:  0.07577807
p_int:  0.999961587
p_ni:  0.000038412
Score:  0.252
Data Source:  BioPlex,STRINGDB
DPEP1
Tclin
Family:  Enzyme
Novelty:  0.00384946
p_int:  0.999891887
p_ni:  0.000108113
Data Source:  BioPlex
ARRDC1
Tbio
Novelty:  0.10481621
p_int:  0.999826598
p_ni:  0.000173401
p_wrong:  1e-9
Data Source:  BioPlex
BMP1
Tchem
Novelty:  0.00299518
p_int:  0.995091406
p_ni:  0.004908588
p_wrong:  6e-9
Data Source:  BioPlex
PIP
Tbio
Novelty:  0.00208509
p_int:  0.994280403
p_ni:  0.005719597
Data Source:  BioPlex
INTU
Tbio
Novelty:  0.02714388
p_int:  0.973404329
p_ni:  0.026595671
Score:  0.193
Data Source:  BioPlex,STRINGDB
GPR137B
Tbio
Novelty:  0.17325252
p_int:  0.969935462
p_ni:  0.030064537
p_wrong:  1e-9
Score:  0.234
Data Source:  BioPlex,STRINGDB
FZD10
Tbio
Family:  GPCR
Novelty:  0.02786933
p_int:  0.96688479
p_ni:  0.033115202
p_wrong:  8e-9
Data Source:  BioPlex
TNFSF13B
Tclin
Novelty:  0.00069885
p_int:  0.966880479
p_ni:  0.03311952
p_wrong:  1e-9
Data Source:  BioPlex
CYB5B
Tbio
Novelty:  0.09395308
p_int:  0.959855828
p_ni:  0.040144172
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Condensation of Prometaphase Chromosomes
Reactome
M Phase
Reactome
Mitotic Prometaphase
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
Condensation of Prometaphase Chromosomes
M Phase
Mitotic Prometaphase
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (9)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (33)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
10
18
28
99.9
birth weight
3
3
3
96.7
appendicular lean mass
3
2
3
94.7
BMI-adjusted hip circumference
2
12
14
84.2
sex hormone-binding globulin measurement
4
2
4
75.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
28
99.9
birth weight
3
96.7
appendicular lean mass
3
94.7
BMI-adjusted hip circumference
14
84.2
sex hormone-binding globulin measurement
4
75.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
non-SMC condensin I complex subunit G
VGNC:2973
471153
Macaque
non-SMC condensin I complex subunit G
715235
Mouse
MGI:1930197
54392
Rat
RGD:1562646
305392
Dog
non-SMC condensin I complex subunit G
VGNC:43641
479132
Species
Name
OMA
EggNOG
Inparanoid
Chimp
non-SMC condensin I complex subunit G
Macaque
non-SMC condensin I complex subunit G
Mouse
Rat
Dog
non-SMC condensin I complex subunit G
Publication Statistics
PubMed Score 103.23
PubMed score by year
PubTator Score 14.77
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title