Tbio NCALD Neurocalcin-delta

Protein Summary

Description

May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds three calcium ions. This gene encodes a member of the neuronal calcium sensor (NCS) family of calcium-binding proteins. The protein contains an N-terminal myristoylation signal and four EF-hand calcium binding loops. The protein is cytosolic at resting calcium levels; however, elevated intracellular calcium levels induce a conformational change that exposes the myristoyl group, resulting in protein association with membranes and partial co-localization with the perinuclear trans-golgi network. The protein is thought to be a regulator of G protein-coupled receptor signal transduction. Several alternatively spliced variants of this gene have been determined, all of which encode the same protein; additional variants may exist but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P61601
• P29554
• Q8IYC3
• Q9H0W2

Gene Name

• NCALD

Ensembl ID

• ENST00000220931
• ENSP00000220931
• ENSG00000104490
• ENST00000311028
• ENSP00000310587
• ENST00000395923
• ENSP00000379256
• ENST00000519508
• ENSP00000430476
• ENST00000521599
• ENSP00000428105

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.79
disease perturbation	0.74
transcription factor	0.71
small molecule perturbation	0.7
disease	0.67

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.01   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 145   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.01   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 145   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

ProtVista Viewer

Expression Data (0 Tissues)

tutorial

No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

Go To Tool

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Go To Tool

Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (107)

Explore Interacting Targets

1 – 10 of 107

• See Interactions on String-DB

NDUFB5

Tclin

Family:  Enzyme

Novelty:  0.0257403

p_int:  0.999678201

p_ni:  0.000321798

p_wrong:  1e-9

Data Source:  BioPlex

VTCN1

Tbio

Novelty:  0.00565174

p_int:  0.995375202

p_ni:  0.004621709

p_wrong:  0.000003089

Score:  0.517

Data Source:  BioPlex,STRINGDB

NUFIP1

Tbio

Novelty:  0.11726869

p_int:  0.991640802

p_ni:  0.008359195

p_wrong:  3e-9

Data Source:  BioPlex

HAX1

Tbio

Novelty:  0.00749205

p_int:  0.928201067

p_ni:  0.071798431

p_wrong:  5.03e-7

Data Source:  BioPlex

DNAAF2

Tbio

Novelty:  0.01254416

p_int:  0.914521198

p_ni:  0.085477959

p_wrong:  8.43e-7

Data Source:  BioPlex

DGUOK

Tbio

Family:  Kinase

Novelty:  0.00897987

p_int:  0.88147218

p_ni:  0.118527713

p_wrong:  1.07e-7

Data Source:  BioPlex

HSPBAP1

Tbio

Novelty:  0.03321047

p_int:  0.87818211

p_ni:  0.121467594

p_wrong:  0.000350296

Score:  0.305

Data Source:  BioPlex,STRINGDB

CLTC

Tbio

Novelty:  0.00256674

Score:  0.939

Data Source:  STRINGDB

GUCY2D

Tbio

Family:  Kinase

Novelty:  0.00578343

Score:  0.936

Data Source:  STRINGDB

DLG4

Tchem

Novelty:  0.00057285

Score:  0.919

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (7)

Reactome (6)

KEGG (1)

Activation of Ca-permeable Kainate Receptor (R-HSA-451308)

Click on a row in the table to change the structure displayed.

Find Similar Targets

Items per page:

5

1 – 5 of 6

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Activation of Ca-permeable Kainate Receptor	10 targets	R-HSA-451308
Reactome	Activation of kainate receptors upon glutamate binding	30 targets	R-HSA-451326
Reactome	Ionotropic activity of kainate receptors	10 targets	R-HSA-451306
Reactome	Neuronal System	398 targets	R-HSA-112316
Reactome	Neurotransmitter receptors and postsynaptic signal transmission	186 targets	R-HSA-112314

Name	Explore in Pharos	Explore in Source
Activation of Ca-permeable Kainate Receptor	10 targets	R-HSA-451308
Activation of kainate receptors upon glutamate binding	30 targets	R-HSA-451326
Ionotropic activity of kainate receptors	10 targets	R-HSA-451306
Neuronal System	398 targets	R-HSA-112316
Neurotransmitter receptors and postsynaptic signal transmission	186 targets	R-HSA-112314

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (11)

Functions (5)

Components (3)

Processes (3)

Find Similar Targets

Items per page:

10

1 – 5 of 5

GO Term	Evidence	Assigned by
actin binding	Inferred from Direct Assay (IDA)	UniProtKB
clathrin binding	Inferred from Direct Assay (IDA)	UniProtKB
tubulin binding	Inferred from Direct Assay (IDA)	UniProtKB
alpha-tubulin binding	Inferred from Electronic Annotation (IEA)	Ensembl
calcium ion binding	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations ()

No disease associations found

GWAS Traits (5)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 5

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
red blood cell distribution width	EFO_0005192	2	1	2		65.9
systolic blood pressure	EFO_0006335	1	1	1		36.9
coronary artery disease	EFO_0001645	1	1	1		24.5
Beta blocking agent use measurement	EFO_0009929	1	1	1		14.2
inflammatory biomarker measurement	EFO_0004872	1	1	0	24890	2.3

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 5

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
red blood cell distribution width	EFO_0005192	2		65.9
systolic blood pressure	EFO_0006335	1		36.9
coronary artery disease	EFO_0001645	1		24.5
Beta blocking agent use measurement	EFO_0009929	1		14.2
inflammatory biomarker measurement	EFO_0004872	0	24890	2.3

Reset Zoom  Beta Count   Odds Ratio

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Calcium
Complete proteome
Lipoprotein
Metal-binding
Myristate
Reference proteome
Repeat

GWAS Trait Find Similar Targets

No Header	No Header
Beta blocking agent use measurement
coronary artery disease
inflammatory biomarker measurement
red blood cell distribution width
systolic blood pressure

MGI Phenotype Find Similar Targets

No Header	No Header
adipose tissue phenotype
behavior/neurological phenotype
cardiovascular system phenotype
growth/size/body region phenotype
homeostasis/metabolism phenotype
mortality/aging
skeleton phenotype
vision/eye phenotype

IDG Resources

No IDG generated resources found

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	neurocalcin delta	VGNC:13190	464321
Macaque	neurocalcin delta		706856
Mouse	neurocalcin delta	MGI:1196326	52589
Rat	neurocalcin delta	RGD:1560287	553106
Dog	neurocalcin delta	VGNC:43635	475053

Species	Name	OMA	EggNOG	Inparanoid
Chimp	neurocalcin delta
Macaque	neurocalcin delta
Mouse	neurocalcin delta
Rat	neurocalcin delta
Dog	neurocalcin delta

Publication Statistics

PubMed Score 30.01

PubMed score by year

Reset Zoom

PubTator Score 12.23

PubTator score by year

Reset Zoom

Related Publications

Text Mined References (32)

GeneRif Annotations (8)

Items per page:

10

0 of 0

PMID	Year	Title