Protein Summary
May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds three calcium ions. This gene encodes a member of the neuronal calcium sensor (NCS) family of calcium-binding proteins. The protein contains an N-terminal myristoylation signal and four EF-hand calcium binding loops. The protein is cytosolic at resting calcium levels; however, elevated intracellular calcium levels induce a conformational change that exposes the myristoyl group, resulting in protein association with membranes and partial co-localization with the perinuclear trans-golgi network. The protein is thought to be a regulator of G protein-coupled receptor signal transduction. Several alternatively spliced variants of this gene have been determined, all of which encode the same protein; additional variants may exist but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
- ENST00000220931
- ENSP00000220931
- ENSG00000104490
- ENST00000311028
- ENSP00000310587
- ENST00000395923
- ENSP00000379256
- ENST00000519508
- ENSP00000430476
- ENST00000521599
- ENSP00000428105
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
virus perturbation | 0.79 | ||
disease perturbation | 0.74 | ||
transcription factor | 0.71 | ||
small molecule perturbation | 0.7 | ||
disease | 0.67 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 30.01 (req: < 5)
Gene RIFs: 8 (req: <= 3)
Antibodies: 145 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 30.01 (req: >= 5)
Gene RIFs: 8 (req: > 3)
Antibodies: 145 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (107)
NDUFB5
Family: Enzyme
Novelty: 0.0257403
p_int: 0.999678201
p_ni: 0.000321798
p_wrong: 1e-9
Data Source: BioPlex
VTCN1
Novelty: 0.00565174
p_int: 0.995375202
p_ni: 0.004621709
p_wrong: 0.000003089
Score: 0.517
Data Source: BioPlex,STRINGDB
NUFIP1
Novelty: 0.11726869
p_int: 0.991640802
p_ni: 0.008359195
p_wrong: 3e-9
Data Source: BioPlex
HAX1
Novelty: 0.00749205
p_int: 0.928201067
p_ni: 0.071798431
p_wrong: 5.03e-7
Data Source: BioPlex
DNAAF2
Novelty: 0.01254416
p_int: 0.914521198
p_ni: 0.085477959
p_wrong: 8.43e-7
Data Source: BioPlex
DGUOK
Family: Kinase
Novelty: 0.00897987
p_int: 0.88147218
p_ni: 0.118527713
p_wrong: 1.07e-7
Data Source: BioPlex
HSPBAP1
Novelty: 0.03321047
p_int: 0.87818211
p_ni: 0.121467594
p_wrong: 0.000350296
Score: 0.305
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (7)
Reactome (6)
KEGG (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Activation of Ca-permeable Kainate Receptor | ||||
Reactome | Activation of kainate receptors upon glutamate binding | ||||
Reactome | Ionotropic activity of kainate receptors | ||||
Reactome | Neuronal System | ||||
Reactome | Neurotransmitter receptors and postsynaptic signal transmission | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Activation of Ca-permeable Kainate Receptor | ||||
Activation of kainate receptors upon glutamate binding | ||||
Ionotropic activity of kainate receptors | ||||
Neuronal System | ||||
Neurotransmitter receptors and postsynaptic signal transmission | ||||
Viral Interactions (0)
Gene Ontology Terms (11)
Functions (5)
Components (3)
Processes (3)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (5)
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
red blood cell distribution width | 2 | 1 | 2 | 65.9 | |||||
systolic blood pressure | 1 | 1 | 1 | 36.9 | |||||
1 | 1 | 1 | 24.5 | ||||||
Beta blocking agent use measurement | 1 | 1 | 1 | 14.2 | |||||
inflammatory biomarker measurement | 1 | 1 | 0 | 24890 | 2.3 | ||||
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
red blood cell distribution width | 2 | 65.9 | |||||
systolic blood pressure | 1 | 36.9 | |||||
1 | 24.5 | ||||||
Beta blocking agent use measurement | 1 | 14.2 | |||||
inflammatory biomarker measurement | 0 | 24890 | 2.3 | ||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | neurocalcin delta | VGNC:13190 | 464321 | |||||
Macaque | neurocalcin delta | 706856 | ||||||
Mouse | MGI:1196326 | 52589 | ||||||
Rat | RGD:1560287 | 553106 | ||||||
Dog | neurocalcin delta | VGNC:43635 | 475053 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | neurocalcin delta | |||||
Macaque | neurocalcin delta | |||||
Mouse | ||||||
Rat | ||||||
Dog | neurocalcin delta | |||||
Publication Statistics
PubMed Score 30.01
PubMed score by year
PubTator Score 12.23
PubTator score by year
Related Publications
Text Mined References (32)
GeneRif Annotations (8)
Items per page:
0 of 0
PMID | Year | Title |
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