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Tbio
NBR1
Next to BRCA1 gene 1 protein

Protein Summary
Description
Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets. The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled-coil motif, which is present in many genes with transformation potential. It functions as a specific autophagy receptor for the selective autophagic degradation of peroxisomes by forming intracellular inclusions with ubiquitylated autophagic substrates. This gene is located on a region of chromosome 17q21.1 that is in close proximity to the BRCA1 tumor suppressor gene. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000341165
  • ENSP00000343479
  • ENSG00000188554
  • ENST00000589872
  • ENSP00000467816
  • ENST00000590996
  • ENSP00000466667

Symbol
  • 1A13B
  • KIAA0049
  • M17S2
  • IAI3B
  • M17S2
  • MIG19
  • 1A1-3B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.97
kinase perturbation
0.93
transcription factor
0.93
gene perturbation
0.85
interacting protein
0.84


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 109.92   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 252   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 109.92   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 252   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (144)
LY86
Tbio
Novelty:  0.00314575
p_int:  0.999976102
p_ni:  0.000023898
Data Source:  BioPlex
JUNB
Tbio
Family:  TF
Novelty:  0.00841656
p_int:  0.999948876
p_ni:  0.000051123
p_wrong:  1e-9
Data Source:  BioPlex
SCGN
Tbio
Novelty:  0.01434518
p_int:  0.999693375
p_ni:  0.000237374
p_wrong:  0.000069251
Score:  0.295
Data Source:  BioPlex,STRINGDB
GSK3A
Tclin
Family:  Kinase
Novelty:  0.00925708
p_int:  0.999647737
p_ni:  0.000352007
p_wrong:  2.56e-7
Score:  0.383
Data Source:  BioPlex,STRINGDB
VAPB
Tbio
Novelty:  0.00542377
p_int:  0.99923952
p_ni:  0.000760479
p_wrong:  1e-9
Score:  0.4
Data Source:  BioPlex,STRINGDB
SPPL2B
Tchem
Family:  Enzyme
Novelty:  0.0274774
p_int:  0.999077549
p_ni:  0.00092126
p_wrong:  0.000001191
Data Source:  BioPlex
TROVE2
Tbio
Novelty:  0.00306038
p_int:  0.999044941
p_ni:  0.000953666
p_wrong:  0.000001392
Data Source:  BioPlex
THEM5
Tbio
Family:  Enzyme
Novelty:  0.20267249
p_int:  0.99895318
p_ni:  0.001032673
p_wrong:  0.000014146
Data Source:  BioPlex
CORO6
Tdark
Novelty:  0.37416507
p_int:  0.998719624
p_ni:  0.001280288
p_wrong:  8.9e-8
Score:  0.201
Data Source:  BioPlex,STRINGDB
MRPL41
Tbio
Novelty:  0.04024303
p_int:  0.998097447
p_ni:  0.001901393
p_wrong:  0.000001161
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at menopause
1
1
1
45.7
monocyte percentage of leukocytes
1
1
1
44.2
age at menarche
1
1
1
17.8
neutrophil count
1
1
1
13.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at menopause
1
45.7
monocyte percentage of leukocytes
1
44.2
age at menarche
1
17.8
neutrophil count
1
13.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NBR1, autophagy cargo receptor
VGNC:10505
455047
Macaque
NBR1, autophagy cargo receptor
708558
Mouse
MGI:108498
17966
Rat
RGD:69195
303554
Dog
NBR1, autophagy cargo receptor
VGNC:43634
480509
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NBR1, autophagy cargo receptor
Macaque
NBR1, autophagy cargo receptor
Mouse
Rat
Dog
NBR1, autophagy cargo receptor
Publication Statistics
PubMed Score 109.92
PubMed score by year
PubTator Score 47.13
PubTator score by year
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Related Publications
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PMID
Year
Title