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Tbio
NBAS
Neuroblastoma-amplified sequence

Protein Summary
Description
Involved in Golgi-to-endoplasmic reticulum (ER) retrograde transport; the function is proposed to depend on its association in the NRZ complex which is believed to play a role in SNARE assembly at the ER (PubMed:19369418). This gene encodes a protein with two leucine zipper domains, a ribosomal protein S14 signature domain and a Sec39 like domain. The protein is thought to be involved in Golgi-to-ER transport. Mutations in this gene are associated with short stature, optic nerve atrophy, and Pelger-Huet anomaly. [provided by RefSeq, Oct 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000281513
  • ENSP00000281513
  • ENSG00000151779

Symbol
  • NAG
  • NAG
  • SOPH
  • ILFS2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.96
histone modification site profile
0.88
kinase perturbation
0.81
cell line
0.77
tissue
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 95.71   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 69   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 95.71   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 69   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (113)
RINT1
Tbio
Novelty:  0.04546291
p_int:  0.999999956
p_ni:  4.4e-8
Score:  0.993
Data Source:  BioPlex,Reactome,STRINGDB
SCFD2
Tdark
Novelty:  0.38252131
p_int:  0.999999905
p_ni:  9.5e-8
Score:  0.943
Data Source:  BioPlex,STRINGDB
STX18
Tbio
Novelty:  0.0259034
p_int:  0.999999611
p_ni:  3.89e-7
Score:  0.995
Data Source:  BioPlex,Reactome,STRINGDB
VAMP5
Tbio
Novelty:  0.09958312
p_int:  0.999998141
p_ni:  0.000001859
Data Source:  BioPlex
USE1
Tbio
Novelty:  0.00904756
p_int:  0.999996716
p_ni:  0.000003284
Score:  0.983
Data Source:  BioPlex,Reactome,STRINGDB
SEC22B
Tbio
Novelty:  0.03035448
p_int:  0.999995993
p_ni:  0.000004007
Score:  0.982
Data Source:  BioPlex,STRINGDB
VAMP4
Tbio
Novelty:  0.02949854
p_int:  0.999953774
p_ni:  0.000046226
Score:  0.676
Data Source:  BioPlex,STRINGDB
STX12
Tbio
Novelty:  0.03836262
p_int:  0.996355808
p_ni:  0.003644188
p_wrong:  4e-9
Score:  0.755
Data Source:  BioPlex,STRINGDB
NAPG
Tbio
Novelty:  0.02295985
p_int:  0.986544826
p_ni:  0.013455174
Score:  0.983
Data Source:  BioPlex,STRINGDB
EFNA5
Tbio
Novelty:  0.00134985
p_int:  0.973664437
p_ni:  0.02633553
p_wrong:  3.3e-8
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
COPI-dependent Golgi-to-ER retrograde traffic (R-HSA-6811434)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
COPI-dependent Golgi-to-ER retrograde traffic
Reactome
Golgi-to-ER retrograde transport
Reactome
Intra-Golgi and retrograde Golgi-to-ER traffic
Reactome
Membrane Trafficking
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
COPI-dependent Golgi-to-ER retrograde traffic
Golgi-to-ER retrograde transport
Intra-Golgi and retrograde Golgi-to-ER traffic
Membrane Trafficking
Vesicle-mediated transport
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (10)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
6
3
5
7.8
90.3
urate measurement
2
2
2
73.8
heel bone mineral density
1
1
1
69
1
2
0
1.4
64.2
self reported educational attainment
2
2
2
39.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
5
7.8
90.3
urate measurement
2
73.8
heel bone mineral density
1
69
0
1.4
64.2
self reported educational attainment
2
39.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
neuroblastoma amplified sequence
VGNC:325
459040
Macaque
neuroblastoma amplified sequence
698203
Mouse
MGI:1918419
71169
Rat
RGD:1585140
690073
Dog
neuroblastoma amplified sequence
482975
Species
Name
OMA
EggNOG
Inparanoid
Chimp
neuroblastoma amplified sequence
Macaque
neuroblastoma amplified sequence
Mouse
Rat
Dog
neuroblastoma amplified sequence
Publication Statistics
PubMed Score 95.71
PubMed score by year
PubTator Score 291.71
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title