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Tbio
NAXD
ATP-dependent (S)-NAD(P)H-hydrate dehydratase

Protein Summary
Description
Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309957
  • ENSP00000311984
  • ENSG00000213995
  • ENST00000424185
  • ENSP00000413191

Symbol
  • CARKD
  • CARKD
  • LP3298
  • PEBEL2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.2   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 62   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.2   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 62   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (66)
FGL1
Tbio
Novelty:  0.02650803
p_int:  0.999923269
p_ni:  0.000076731
Score:  0.187
Data Source:  BioPlex,STRINGDB
EIF1AD
Tdark
Novelty:  0.23915521
p_int:  0.991995521
p_ni:  0.007819934
p_wrong:  0.000184545
Data Source:  BioPlex
PPT2
Tbio
Family:  Enzyme
Novelty:  0.00829249
p_int:  0.942459563
p_ni:  0.057436555
p_wrong:  0.000103882
Score:  0.223
Data Source:  BioPlex,STRINGDB
PHEX
Tbio
Family:  Enzyme
Novelty:  0.00258726
p_int:  0.917716058
p_ni:  0.082283815
p_wrong:  1.27e-7
Score:  0.369
Data Source:  BioPlex,STRINGDB
SLC25A30
Tdark
Family:  Transporter
Novelty:  0.42665445
p_int:  0.908679459
p_ni:  0.091215556
p_wrong:  0.000104985
Score:  0.157
Data Source:  BioPlex,STRINGDB
MKLN1
Tbio
Novelty:  0.05014385
p_int:  0.881762755
p_ni:  0.118237245
Data Source:  BioPlex
CYB5D2
Tbio
Novelty:  0.23122479
p_int:  0.869519896
p_ni:  0.130480104
Score:  0.177
Data Source:  BioPlex,STRINGDB
P04439
Tclin
Novelty:  0.00270731
p_int:  0.796387237
p_ni:  0.203612763
Score:  0.169
Data Source:  BioPlex,STRINGDB
LINGO2
Tbio
Novelty:  0.06112205
p_int:  0.793771326
p_ni:  0.206228674
p_wrong:  1e-9
Score:  0.181
Data Source:  BioPlex,STRINGDB
BCL6
Tchem
Family:  TF
Novelty:  0.00066258
p_int:  0.777512839
p_ni:  0.222448992
p_wrong:  0.000038169
Score:  0.369
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of vitamins and cofactors
Reactome
Metabolism of water-soluble vitamins and cofactors
Reactome
Nicotinamide salvaging
Reactome
Nicotinate metabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of vitamins and cofactors
Metabolism of water-soluble vitamins and cofactors
Nicotinamide salvaging
Nicotinate metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
erosive tooth wear measurement
1
2
0
6
46.7
aspartate aminotransferase measurement
1
1
0
6.7
37.7
C-reactive protein measurement
1
1
1
28.6
sex hormone-binding globulin measurement
1
1
1
25.8
serum gamma-glutamyl transferase measurement
1
1
1
3.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
erosive tooth wear measurement
0
6
46.7
aspartate aminotransferase measurement
0
6.7
37.7
C-reactive protein measurement
1
28.6
sex hormone-binding globulin measurement
1
25.8
serum gamma-glutamyl transferase measurement
1
3.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NAD(P)HX dehydratase
VGNC:13232
452663
Macaque
NAD(P)HX dehydratase
694722
Mouse
MGI:1913353
69225
Rat
RGD:1562691
361185
Dog
NAD(P)HX dehydratase [Source:HGNC Symbol;Acc:HGNC:25576]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NAD(P)HX dehydratase
Macaque
NAD(P)HX dehydratase
Mouse
Rat
Dog
NAD(P)HX dehydratase [Source:HGNC Symbol;Acc:HGNC:25576]
Publication Statistics
PubMed Score 22.20
PubMed score by year
PubTator Score 1.50
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title