You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
NAT8B
Putative N-acetyltransferase 8B

Protein Summary
Description
May have a lysine N-acetyltransferase activity catalyzing peptidyl-lysine N6-acetylation of various proteins. Thereby, may regulate apoptosis through the acetylation and the regulation of the expression of PROM1 (PubMed:24556617). May also regulate amyloid beta-peptide secretion through acetylation of BACE1 and the regulation of its expression in neurons (PubMed:19011241). The protein encoded by this gene is highly similar to the N-acetyltransferase 8 (NAT8) gene product, which is a kidney and liver protein with homology to bacterial acetyltransferases involved in drug resistance. This gene is localized on chromosome 2 in the vicinity of the NAT8 gene and may represent a pseudogene of NAT8. This gene contains two polymorphic nonsense mutations that disrupt the active site of the protein. The full-length product of this gene contains a complete acetyltransferase domain and is identical in length to NAT8. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Symbol
  • CML2
  • CML2
  • Hcml2
  • NAT8BP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.71
virus perturbation
0.68
transcription factor perturbation
0.61
cell type or tissue
0.54
PubMedID
0.54


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (18)
DPY19L4
Tdark
Family:  Enzyme
Novelty:  0.99997412
p_int:  0.99992353
p_ni:  0.000076333
p_wrong:  1.37e-7
Data Source:  BioPlex
CD82
Tbio
Novelty:  0.00146542
p_int:  0.999766475
p_ni:  5e-9
p_wrong:  0.00023352
Data Source:  BioPlex
UQCRQ
Tbio
Novelty:  0.04392627
p_int:  0.99384279
p_ni:  0.006035239
p_wrong:  0.000121971
Data Source:  BioPlex
NAT8
Tbio
Family:  Enzyme
Novelty:  0.02178437
p_int:  0.98906579
p_ni:  5e-9
p_wrong:  0.010934205
Data Source:  BioPlex
SERPINE2
Tbio
Novelty:  0.00246375
p_int:  0.988226686
p_ni:  0.011719687
p_wrong:  0.000053627
Data Source:  BioPlex
ABCC4
Tchem
Family:  Transporter
Novelty:  0.00208051
p_int:  0.986811747
p_ni:  0.013142282
p_wrong:  0.000045971
Data Source:  BioPlex
RTN2
Tbio
Novelty:  0.05184418
p_int:  0.981168231
p_ni:  0.004269647
p_wrong:  0.014562122
Data Source:  BioPlex
SLC7A2
Tbio
Family:  Transporter
Novelty:  0.02262224
p_int:  0.977846833
p_ni:  0.022152396
p_wrong:  7.71e-7
Data Source:  BioPlex
GHITM
Tbio
Novelty:  0.00360652
p_int:  0.955738795
p_ni:  0.044261204
p_wrong:  1e-9
Data Source:  BioPlex
VPS13A
Tbio
Novelty:  0.00581335
p_int:  0.917507785
p_ni:  0.082492215
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Amyloid fiber formation (R-HSA-977225)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amyloid fiber formation
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Amyloid fiber formation
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Xenopus
probable N-acetyltransferase CML5
100489204
Species
Name
OMA
EggNOG
Inparanoid
Xenopus
probable N-acetyltransferase CML5
Publication Statistics
PubTator Score 20.14
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title