Pharos : Target Details

Tbio

Protein Summary

Description

May have a lysine N-acetyltransferase activity catalyzing peptidyl-lysine N6-acetylation of various proteins. Thereby, may regulate apoptosis through the acetylation and the regulation of the expression of PROM1 (PubMed:24556617). May also regulate amyloid beta-peptide secretion through acetylation of BACE1 and the regulation of its expression in neurons (PubMed:19011241). The protein encoded by this gene is highly similar to the N-acetyltransferase 8 (NAT8) gene product, which is a kidney and liver protein with homology to bacterial acetyltransferases involved in drug resistance. This gene is localized on chromosome 2 in the vicinity of the NAT8 gene and may represent a pseudogene of NAT8. This gene contains two polymorphic nonsense mutations that disrupt the active site of the protein. The full-length product of this gene contains a complete acetyltransferase domain and is identical in length to NAT8. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

Gene Name

NAT8B

Symbol

CML2
CML2
Hcml2
NAT8BP

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.71

virus perturbation	0.68

transcription factor perturbation	0.61

cell type or tissue	0.54

PubMedID	0.54

Protein Classes

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0 (req: < 5)

View Publications

Gene RIFs: 2 (req: <= 3)

View Gene RIFs

Antibodies: 0 (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0 (req: >= 5)

Gene RIFs: 2 (req: > 3)

Antibodies: 0 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

View GO Terms

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Related Tools (3)

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Go To Tool

Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (18)

Explore Interacting Targets

1 – 10 of 18

See Interactions on String-DB

DPY19L4

Tdark

Family: Enzyme

Novelty: 0.99997412

p_int: 0.99992353

p_ni: 0.000076333

p_wrong: 1.37e-7

Data Source: BioPlex

CD82

Tbio

Novelty: 0.00146542

p_int: 0.999766475

p_ni: 5e-9

p_wrong: 0.00023352

Data Source: BioPlex

UQCRQ

Tbio

Novelty: 0.04392627

p_int: 0.99384279

p_ni: 0.006035239

p_wrong: 0.000121971

Data Source: BioPlex

NAT8

Tbio

Family: Enzyme

Novelty: 0.02178437

p_int: 0.98906579

p_ni: 5e-9

p_wrong: 0.010934205

Data Source: BioPlex

SERPINE2

Tbio

Novelty: 0.00246375

p_int: 0.988226686

p_ni: 0.011719687

p_wrong: 0.000053627

Data Source: BioPlex

ABCC4

Tchem

Family: Transporter

Novelty: 0.00208051

p_int: 0.986811747

p_ni: 0.013142282

p_wrong: 0.000045971

Data Source: BioPlex

RTN2

Tbio

Novelty: 0.05184418

p_int: 0.981168231

p_ni: 0.004269647

p_wrong: 0.014562122

Data Source: BioPlex

SLC7A2

Tbio

Family: Transporter

Novelty: 0.02262224

p_int: 0.977846833

p_ni: 0.022152396

p_wrong: 7.71e-7

Data Source: BioPlex

GHITM

Tbio

Novelty: 0.00360652

p_int: 0.955738795

p_ni: 0.044261204

p_wrong: 1e-9

Data Source: BioPlex

VPS13A

Tbio

Novelty: 0.00581335

p_int: 0.917507785

p_ni: 0.082492215

Data Source: BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (4)

Reactome (2)

KEGG (2)

Amyloid fiber formation (R-HSA-977225)

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Items per page:

1 – 2 of 2

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Amyloid fiber formation	79 targets	R-HSA-977225

Reactome	Metabolism of proteins	2050 targets	R-HSA-392499

Name	Explore in Pharos	Explore in Source
Amyloid fiber formation	79 targets	R-HSA-977225

Metabolism of proteins	2050 targets	R-HSA-392499

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (12)

Functions (2)

Components (4)

Processes (6)

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Items per page:

1 – 2 of 2

GO Term	Evidence	Assigned by
lysine N-acetyltransferase activity, acting on acetyl phosphate as donor	Inferred from Direct Assay (IDA)	UniProtKB

N-acetyltransferase activity	Non-traceable Author Statement (NAS)	UniProtKB

Disease Associations (null)

No disease associations found

GWAS Traits (0)

No GWAS traits found

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UniProt Keyword

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No Header	No Header
Acyltransferase

Complete proteome

Endoplasmic reticulum

Membrane

Reference proteome

Signal-anchor

Transferase

Transmembrane

Transmembrane helix

IDG Resources

No IDG generated resources found

Orthologs (1)

1 – 1 of 1

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Xenopus	probable N-acetyltransferase CML5		100489204

Species	Name	OMA	EggNOG	Inparanoid
Xenopus	probable N-acetyltransferase CML5

Publication Statistics

PubTator Score 20.14

PubTator score by year

Related Publications

Text Mined References (9)

GeneRif Annotations (2)

Items per page:

0 of 0

PMID	Year	Title