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Tbio
NAT14
N-acetyltransferase 14

Protein Summary
Description
Probable acetyltransferase that binds the 5'-GGACTACAG-3' sequence of coproporphyrinogen oxidase promoter. Able to activate transcription of a reporter construct in vitro.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000205194
  • ENSP00000205194
  • ENSG00000090971

Symbol
  • KLP1
  • KLP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.72
histone modification site profile
0.58
tissue sample
0.55
transcription factor
0.54
cell line
0.51


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.22   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 88   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.22   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 88   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (40)
PEX19
Tbio
Novelty:  0.00605342
p_int:  0.999955352
p_ni:  0.000044648
Data Source:  BioPlex
SLC39A5
Tbio
Family:  Transporter
Novelty:  0.05205571
p_int:  0.995076797
p_ni:  0.004923203
Data Source:  BioPlex
HEPACAM2
Tbio
Novelty:  0.19192547
p_int:  0.989923067
p_ni:  0.010076933
Data Source:  BioPlex
CMKLR1
Tchem
Family:  GPCR
Novelty:  0.00893083
p_int:  0.982027109
p_ni:  0.01797289
p_wrong:  1e-9
Data Source:  BioPlex
CPVL
Tbio
Family:  Enzyme
Novelty:  0.0616903
p_int:  0.976177053
p_ni:  0.023822947
Score:  0.177
Data Source:  BioPlex,STRINGDB
KCNA10
Tclin
Family:  IC
Novelty:  0.05708808
p_int:  0.975719253
p_ni:  0.024280747
Score:  0.383
Data Source:  BioPlex,STRINGDB
TRDN
Tbio
Novelty:  0.00501554
p_int:  0.943451313
p_ni:  0.056548679
p_wrong:  8e-9
Data Source:  BioPlex
SLC39A12
Tbio
Family:  Transporter
Novelty:  0.09127395
p_int:  0.927277592
p_ni:  0.072722378
p_wrong:  3e-8
Data Source:  BioPlex
UPK1A
Tbio
Novelty:  0.01748122
p_int:  0.894297421
p_ni:  0.105702578
p_wrong:  1e-9
Data Source:  BioPlex
SLC6A20
Tbio
Family:  Transporter
Novelty:  0.01435823
p_int:  0.870680002
p_ni:  0.129301074
p_wrong:  0.000018924
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (21)
Find Similar Targets
Items per page:
1 – 5 of 21
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Metapathway biotransformation Phase I and II
WikiPathways
Metapathway biotransformation Phase I and II
WikiPathways
Metapathway biotransformation Phase I and II
WikiPathways
Metapathway biotransformation Phase I and II
WikiPathways
Metapathway biotransformation Phase I and II
Name
Explore in Pharos
Explore in Source
Metapathway biotransformation Phase I and II
Metapathway biotransformation Phase I and II
Metapathway biotransformation Phase I and II
Metapathway biotransformation Phase I and II
Metapathway biotransformation Phase I and II
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
3
1
3
80.4
BMI-adjusted hip circumference
1
1
1
42.3
BMI-adjusted waist-hip ratio
2
1
2
34.7
birth weight
1
1
1
33.1
waist-hip ratio
3
1
3
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
3
80.4
BMI-adjusted hip circumference
1
42.3
BMI-adjusted waist-hip ratio
2
34.7
birth weight
1
33.1
waist-hip ratio
3
21.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
N-acetyltransferase 14 (putative)
VGNC:7788
736425
Macaque
N-acetyltransferase 14 (putative) [Source:HGNC Symbol;Acc:HGNC:28918]
Mouse
MGI:3039561
269854
Rat
RGD:1565991
361500
Dog
N-acetyltransferase 14 (putative)
611287
Species
Name
OMA
EggNOG
Inparanoid
Chimp
N-acetyltransferase 14 (putative)
Macaque
N-acetyltransferase 14 (putative) [Source:HGNC Symbol;Acc:HGNC:28918]
Mouse
Rat
Dog
N-acetyltransferase 14 (putative)
Publication Statistics
PubMed Score 8.22
PubMed score by year
PubTator Score 3.75
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title