Tbio NAPG Gamma-soluble NSF attachment protein

Protein Summary

Description

Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus. This gene encodes soluble NSF attachment protein gamma. The soluble NSF attachment proteins (SNAPs) enable N-ethyl-maleimide-sensitive fusion protein (NSF) to bind to target membranes. NSF and SNAPs appear to be general components of the intracellular membrane fusion apparatus, and their action at specific sites of fusion must be controlled by SNAP receptors particular to the membranes being fused. The product of this gene mediates platelet exocytosis and controls the membrane fusion events of this process.[provided by RefSeq, Dec 2008]

Uniprot Accession IDs

• Q99747
• B4DFC9
• Q9BUV1
• SNAP-gamma

Gene Name

• NAPG

Ensembl ID

• ENST00000322897
• ENSP00000324628
• ENSG00000134265

Symbol

• SNAPG
• GAMMASNAP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.96
virus perturbation	0.96
transcription factor perturbation	0.88
cellular component	0.82
gene perturbation	0.65

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.22   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 172   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.22   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 172   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (189)

Explore Interacting Targets

1 – 10 of 189

• See Interactions on String-DB

VAMP4

Tbio

Novelty:  0.02949854

p_int:  0.999999999

p_ni:  1e-9

Score:  0.98

Data Source:  BioPlex,STRINGDB

STX7

Tbio

Novelty:  0.03109969

p_int:  0.999999996

p_ni:  4e-9

Score:  0.889

Data Source:  BioPlex,STRINGDB

VTI1B

Tbio

Novelty:  0.00955467

p_int:  0.999999837

p_ni:  1.63e-7

Score:  0.863

Data Source:  BioPlex,STRINGDB

STX12

Tbio

Novelty:  0.03836262

p_int:  0.999999768

p_ni:  2.32e-7

Score:  0.858

Data Source:  BioPlex,STRINGDB

VAMP5

Tbio

Novelty:  0.09958312

p_int:  0.999897318

p_ni:  0.000102678

p_wrong:  3e-9

Score:  0.641

Data Source:  BioPlex,STRINGDB

STX8

Tbio

Novelty:  0.01083752

p_int:  0.999877887

p_ni:  0.000122113

Score:  0.943

Data Source:  BioPlex,STRINGDB

PRKAR1B

Tbio

Family:  Enzyme

Novelty:  0.05355517

p_int:  0.999145942

p_ni:  0.000854038

p_wrong:  2e-8

Score:  0.437

Data Source:  BioPlex,STRINGDB

THRSP

Tbio

Novelty:  0.00938864

p_int:  0.999035471

p_ni:  0.000964528

Data Source:  BioPlex

PIPOX

Tbio

Family:  Enzyme

Novelty:  0.04107707

p_int:  0.998580032

p_ni:  0.001419874

p_wrong:  9.4e-8

Score:  0.163

Data Source:  BioPlex,STRINGDB

STXBP6

Tbio

Novelty:  0.13195671

p_int:  0.998563973

p_ni:  0.001410239

p_wrong:  0.000025789

Score:  0.823

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (14)

Reactome (14)

Asparagine N-linked glycosylation (R-HSA-446203)

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1 – 5 of 14

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Asparagine N-linked glycosylation	286 targets	R-HSA-446203
Reactome	COPI-dependent Golgi-to-ER retrograde traffic	83 targets	R-HSA-6811434
Reactome	COPI-mediated anterograde transport	83 targets	R-HSA-6807878
Reactome	COPII-mediated vesicle transport	68 targets	R-HSA-204005
Reactome	ER to Golgi Anterograde Transport	136 targets	R-HSA-199977

Name	Explore in Pharos	Explore in Source
Asparagine N-linked glycosylation	286 targets	R-HSA-446203
COPI-dependent Golgi-to-ER retrograde traffic	83 targets	R-HSA-6811434
COPI-mediated anterograde transport	83 targets	R-HSA-6807878
COPII-mediated vesicle transport	68 targets	R-HSA-204005
ER to Golgi Anterograde Transport	136 targets	R-HSA-199977

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (14)

Functions (2)

Components (7)

Processes (5)

Find Similar Targets

Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
soluble NSF attachment protein activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
syntaxin binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Disease Associations (null)

No disease associations found

GWAS Traits (2)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 2 of 2

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
balding measurement	EFO_0007825	1	1	1		27.3
Alopecia	Orphanet_79364	1	1	1		4.6

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 2 of 2

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
balding measurement	EFO_0007825	1		27.3
Alopecia	Orphanet_79364	1		4.6

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UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Complete proteome
ER-Golgi transport
Membrane
Phosphoprotein
Polymorphism
Protein transport
Reference proteome
Transport

GWAS Trait Find Similar Targets

No Header	No Header
Alopecia
balding measurement

IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	NSF attachment protein gamma	VGNC:7326	468475
Mouse	N-ethylmaleimide sensitive fusion protein attachment protein gamma	MGI:104561	108123
Rat	NSF attachment protein gamma	RGD:1310109	307382
Dog	NSF attachment protein gamma	VGNC:43622	608647
Horse	NSF attachment protein gamma	VGNC:20562	100050057

Species	Name	OMA	EggNOG	Inparanoid
Chimp	NSF attachment protein gamma
Mouse	N-ethylmaleimide sensitive fusion protein attachment protein gamma
Rat	NSF attachment protein gamma
Dog	NSF attachment protein gamma
Horse	NSF attachment protein gamma

Publication Statistics

PubMed Score 49.22

PubMed score by year

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PubTator Score 35.75

PubTator score by year

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Related Publications

Text Mined References (27)

GeneRif Annotations (4)

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10

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PMID	Year	Title