Tbio NAPG Gamma-soluble NSF attachment protein

Protein Summary

Description

Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus. This gene encodes soluble NSF attachment protein gamma. The soluble NSF attachment proteins (SNAPs) enable N-ethyl-maleimide-sensitive fusion protein (NSF) to bind to target membranes. NSF and SNAPs appear to be general components of the intracellular membrane fusion apparatus, and their action at specific sites of fusion must be controlled by SNAP receptors particular to the membranes being fused. The product of this gene mediates platelet exocytosis and controls the membrane fusion events of this process.[provided by RefSeq, Dec 2008]

Uniprot Accession IDs

• Q99747
• B4DFC9
• Q9BUV1
• SNAP-gamma

Gene Name

• NAPG

Ensembl ID

• ENST00000322897
• ENSP00000324628
• ENSG00000134265

Symbol

• SNAPG
• GAMMASNAP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.96
virus perturbation	0.96
transcription factor perturbation	0.88
cellular component	0.82
gene perturbation	0.65

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.81   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 172   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.81   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 172   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0