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Tdark
NAPB
Beta-soluble NSF attachment protein

Protein Summary
Description
Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus. This gene encodes a member of the soluble N-ethyl-maleimide-sensitive fusion attachment protein (SNAP) family. SNAP proteins play a critical role in the docking and fusion of vesicles to target membranes as part of the 20S NSF-SNAP-SNARE complex. This gene encodes the SNAP beta isoform which has been shown to be preferentially expressed in brain tissue. The encoded protein also interacts with the GluR2 α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptor subunit C-terminus and may play a role as a chaperone in the molecular processing of the AMPA receptor. [provided by RefSeq, Mar 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000377026
  • ENSP00000366225
  • ENSG00000125814
  • ENST00000398425
  • ENSP00000381459
  • ENST00000432543
  • ENSP00000413600

Symbol
  • SNAPB
  • SNAPB
  • SNAP-BETA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.8
kinase perturbation
0.71
cell line
0.67
microRNA
0.58
transcription factor binding site profile
0.52


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.26   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 100   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.26   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 100   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (174)
STX12
Tbio
Novelty:  0.03836262
p_int:  0.999998817
p_ni:  5.81e-7
p_wrong:  6.02e-7
Score:  0.77
Data Source:  BioPlex,STRINGDB
VAMP4
Tbio
Novelty:  0.02949854
p_int:  0.999982921
p_ni:  9.18e-7
p_wrong:  0.000016161
Score:  0.955
Data Source:  BioPlex,STRINGDB
DNAAF2
Tbio
Novelty:  0.01254416
p_int:  0.999980088
p_ni:  0.000019597
p_wrong:  3.15e-7
Data Source:  BioPlex
HAX1
Tbio
Novelty:  0.00749205
p_int:  0.999977884
p_ni:  0.000020755
p_wrong:  0.000001361
Data Source:  BioPlex
DGUOK
Tbio
Family:  Kinase
Novelty:  0.00897987
p_int:  0.999918549
p_ni:  0.000021884
p_wrong:  0.000059567
Data Source:  BioPlex
NUFIP1
Tbio
Novelty:  0.11726869
p_int:  0.999797712
p_ni:  0.000079762
p_wrong:  0.000122526
Data Source:  BioPlex
STX16
Tbio
Novelty:  0.02462523
Score:  0.995
Data Source:  STRINGDB
YKT6
Tbio
Novelty:  0.01591063
Score:  0.983
Data Source:  STRINGDB
VTI1A
Tbio
Novelty:  0.04616617
Score:  0.982
Data Source:  STRINGDB
SCFD1
Tbio
Novelty:  0.02924747
Score:  0.981
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (14)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
COPI-dependent Golgi-to-ER retrograde traffic
Reactome
COPI-mediated anterograde transport
Reactome
COPII-mediated vesicle transport
Reactome
ER to Golgi Anterograde Transport
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
COPI-dependent Golgi-to-ER retrograde traffic
COPI-mediated anterograde transport
COPII-mediated vesicle transport
ER to Golgi Anterograde Transport
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
5.7
3.4
age at onset
1
1
0
5.7
3.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
5.7
3.4
age at onset
0
5.7
3.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NSF attachment protein beta
VGNC:6199
458139
Macaque
NSF attachment protein beta
712165
Mouse
MGI:104562
17957
Rat
RGD:1589649
499903
Dog
NSF attachment protein beta
VGNC:43620
477131
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NSF attachment protein beta
Macaque
NSF attachment protein beta
Mouse
Rat
Dog
NSF attachment protein beta
Publication Statistics
PubMed Score 2.26
PubMed score by year
PubTator Score 35.01
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title