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Tbio
NAPA
Alpha-soluble NSF attachment protein

Protein Summary
Description
Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus (Probable). Together with GNA12 promotes CDH5 localization to plasma membrane (PubMed:15980433). This gene encodes a member of the soluble NSF attachment protein (SNAP) family. SNAP proteins play a critical role in the docking and fusion of vesicles to target membranes as part of the 20S NSF-SNAP-SNARE complex. The encoded protein plays a role in the completion of membrane fusion by mediating the interaction of N-ethylmaleimide-sensitive factor (NSF) with the vesicle-associated and membrane-associated SNAP receptor (SNARE) complex, and stimulating the ATPase activity of NSF. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jun 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263354
  • ENSP00000263354
  • ENSG00000105402

Symbol
  • SNAPA
  • SNAPA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.98
disease perturbation
0.95
transcription factor binding site profile
0.81
transcription factor
0.74
cellular component
0.69


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 167.65   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 237   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 167.65   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 237   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (237)
STX12
Tbio
Novelty:  0.03836262
p_int:  0.99960186
p_ni:  0.00039814
Score:  0.971
Data Source:  BioPlex,STRINGDB
VAMP4
Tbio
Novelty:  0.02949854
p_int:  0.998159288
p_ni:  0.001840712
Score:  0.988
Data Source:  BioPlex,Reactome,STRINGDB
SEC22B
Tbio
Novelty:  0.03035448
p_int:  0.998155394
p_ni:  0.001844606
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
VTI1B
Tbio
Novelty:  0.00955467
p_int:  0.994900872
p_ni:  0.005099128
Score:  0.976
Data Source:  BioPlex,STRINGDB
STX7
Tbio
Novelty:  0.03109969
p_int:  0.958614846
p_ni:  0.041385154
Score:  0.973
Data Source:  BioPlex,STRINGDB
VAMP5
Tbio
Novelty:  0.09958312
p_int:  0.932790066
p_ni:  0.067209934
Score:  0.82
Data Source:  BioPlex,STRINGDB
STXBP6
Tbio
Novelty:  0.13195671
p_int:  0.913454345
p_ni:  0.086545655
Score:  0.874
Data Source:  BioPlex,STRINGDB
NAPG
Tbio
Novelty:  0.02295985
p_int:  0.889925083
p_ni:  0.110074917
Score:  0.997
Data Source:  BioPlex,STRINGDB
RINT1
Tbio
Novelty:  0.04546291
p_int:  0.794458258
p_ni:  0.205541742
Score:  0.966
Data Source:  BioPlex,STRINGDB
STX16
Tbio
Novelty:  0.02462523
Score:  0.998
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (18)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
COPI-dependent Golgi-to-ER retrograde traffic
Reactome
COPI-mediated anterograde transport
Reactome
COPII-mediated vesicle transport
Reactome
ER to Golgi Anterograde Transport
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
COPI-dependent Golgi-to-ER retrograde traffic
COPI-mediated anterograde transport
COPII-mediated vesicle transport
ER to Golgi Anterograde Transport
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (30)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
ParkinsonsUK-UCL
Inferred from Sequence or structural Similarity (ISS)
ParkinsonsUK-UCL
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
2
4
70.2
1
1
0
2.6
57.8
serum gamma-glutamyl transferase measurement
1
1
1
51.7
gait measurement
1
1
1
21.5
gut microbiome measurement
1
1
0
5.5
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
70.2
0
2.6
57.8
serum gamma-glutamyl transferase measurement
1
51.7
gait measurement
1
21.5
gut microbiome measurement
0
5.5
15.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NSF attachment protein alpha
VGNC:6638
456168
Macaque
NSF attachment protein alpha
717355
Mouse
MGI:104563
108124
Rat
RGD:620855
140673
Dog
NSF attachment protein alpha
VGNC:43619
612960
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NSF attachment protein alpha
Macaque
NSF attachment protein alpha
Mouse
Rat
Dog
NSF attachment protein alpha
Publication Statistics
PubMed Score 167.65
PubMed score by year
PubTator Score 143.97
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title