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Tbio
NANS
Sialic acid synthase

Protein Summary
Description
Produces N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN). Can also use N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of Neu5Ac and KDN, respectively. This gene encodes an enzyme that functions in the biosynthetic pathways of sialic acids. In vitro, the encoded protein uses N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN), respectively; however, it exhibits much higher activity toward the Neu5Ac phosphate product. In insect cells, expression of this gene results in Neu5Ac and KDN production. This gene is related to the E. coli sialic acid synthase gene neuB, and it can partially restore sialic acid synthase activity in an E. coli neuB-negative mutant. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000210444
  • ENSP00000210444
  • ENSG00000095380

Symbol
  • SAS
  • SAS
  • SEMDG
  • SEMDCG
  • HEL-S-100
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
disease perturbation
0.98
virus perturbation
0.83
protein domain
0.73
transcription factor
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 144.46   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 200   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 144.46   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 200   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (93)
CMAS
Tbio
Family:  Enzyme
Novelty:  0.04295627
Score:  0.996
Data Source:  STRINGDB
GNE
Tbio
Family:  Enzyme
Novelty:  0.00285751
Score:  0.989
Data Source:  STRINGDB
NANP
Tbio
Family:  Enzyme
Novelty:  0.01876342
Score:  0.97
Data Source:  STRINGDB
NPL
Tbio
Family:  Enzyme
Novelty:  0.00944797
Score:  0.965
Data Source:  STRINGDB
RENBP
Tbio
Family:  Enzyme
Novelty:  0.02220005
Score:  0.941
Data Source:  STRINGDB
ASS1
Tbio
Family:  Enzyme
Novelty:  0.00358761
Score:  0.873
Data Source:  STRINGDB
GLOD4
Tbio
Family:  Enzyme
Novelty:  0.11482749
Score:  0.87
Data Source:  STRINGDB
DAZAP1
Tbio
Novelty:  0.04307077
Score:  0.87
Data Source:  STRINGDB
PRDX1
Tchem
Novelty:  0.00207935
Score:  0.822
Data Source:  STRINGDB
PIR
Tchem
Novelty:  0.00327695
Score:  0.819
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Sialic acid metabolism
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Metabolism of proteins
Post-translational protein modification
Sialic acid metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
1
1
83.1
red blood cell density measurement
1
1
1
81.3
eosinophil count
2
1
2
52
reticulocyte count
1
1
1
50.6
mean reticulocyte volume
1
1
1
50.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
83.1
red blood cell density measurement
1
81.3
eosinophil count
2
52
reticulocyte count
1
50.6
mean reticulocyte volume
1
50.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
N-acetylneuraminate synthase
VGNC:4796
743934
Mouse
MGI:2149820
94181
Rat
RGD:1311943
298071
Dog
N-acetylneuraminate synthase
VGNC:43615
481624
Horse
N-acetylneuraminate synthase
VGNC:20556
100064126
Species
Name
OMA
EggNOG
Inparanoid
Chimp
N-acetylneuraminate synthase
Mouse
Rat
Dog
N-acetylneuraminate synthase
Horse
N-acetylneuraminate synthase
Publication Statistics
PubMed Score 144.46
PubMed score by year
PubTator Score 21.11
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title