Tbio NANS Sialic acid synthase

Protein Summary

Description

Produces N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN). Can also use N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of Neu5Ac and KDN, respectively. This gene encodes an enzyme that functions in the biosynthetic pathways of sialic acids. In vitro, the encoded protein uses N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN), respectively; however, it exhibits much higher activity toward the Neu5Ac phosphate product. In insect cells, expression of this gene results in Neu5Ac and KDN production. This gene is related to the E. coli sialic acid synthase gene neuB, and it can partially restore sialic acid synthase activity in an E. coli neuB-negative mutant. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9NR45
• B2RE98
• Q8WUV9
• Q9BWS6
• Q9NVD4

Gene Name

• NANS

Ensembl ID

• ENST00000210444
• ENSP00000210444
• ENSG00000095380

Symbol

• SAS
• SAS
• SEMDG
• SEMDCG
• HEL-S-100

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.99
disease perturbation	0.98
virus perturbation	0.83
protein domain	0.73
transcription factor	0.69

Protein Classes

PANTHER Classes

Protein / Transferase / Acetyltransferase / Sialic Acid Synthase

Protein / Lyase / Sialic Acid Synthase

DTO Classes

Protein / Enzyme / Transferase / Acetyltransferase / Sialic Acid Synthase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 165.17   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 200   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 165.17   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 200   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0