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Tbio
NANOS3
Nanos homolog 3

Protein Summary
Description
Plays a role in the maintenance of the undifferentiated state of germ cells regulating the spermatogonia cell cycle and inducing a prolonged transit in G1 phase. Affects cell proliferation probably by repressing translation of specific mRNAs. Maintains the germ cell lineage by suppressing both Bax-dependent and -independent apoptotic pathways. Essential in the early stage embryo to protect the migrating primordial germ cells (PGCs) from apoptosis.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000339133
  • ENSP00000341992
  • ENSG00000187556
  • ENST00000397555
  • ENSP00000380687

Symbol
  • NOS3
  • NOS3
  • NANOS1L
  • ZC2HC12C
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.67
cell type or tissue
0.66
tissue
0.64
PubMedID
0.58
cellular component
0.54


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.7   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 112   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.7   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 112   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (62)
PUM2
Tbio
Novelty:  0.01849765
Score:  0.921
Data Source:  STRINGDB
DND1
Tbio
Novelty:  0.0287312
Score:  0.88
Data Source:  STRINGDB
DAZL
Tbio
Novelty:  0.00421428
Score:  0.844
Data Source:  STRINGDB
CNOT1
Tbio
Novelty:  0.00362753
Score:  0.835
Data Source:  STRINGDB
TDRD7
Tbio
Family:  Epigenetic
Novelty:  0.03580848
Score:  0.814
Data Source:  STRINGDB
PRDM14
Tbio
Family:  TF; Epigenetic
Novelty:  0.01776592
Score:  0.804
Data Source:  STRINGDB
PUM1
Tbio
Novelty:  0.01536723
Score:  0.784
Data Source:  STRINGDB
PIWIL1
Tbio
Novelty:  0.00095911
Score:  0.772
Data Source:  STRINGDB
DMRT1
Tbio
Family:  TF
Novelty:  0.00403133
Score:  0.743
Data Source:  STRINGDB
PRDM1
Tbio
Family:  TF; Epigenetic
Novelty:  0.00224931
Score:  0.702
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (16)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
3
3
97
leukocyte count
2
2
2
79.3
myeloid white cell count
1
1
1
77.4
lymphocyte percentage of leukocytes
1
1
1
75.7
neutrophil percentage of leukocytes
1
1
1
75.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
97
leukocyte count
2
79.3
myeloid white cell count
1
77.4
lymphocyte percentage of leukocytes
1
75.7
neutrophil percentage of leukocytes
1
75.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nanos C2HC-type zinc finger 3
VGNC:11192
747879
Macaque
nanos C2HC-type zinc finger 3
717410
Mouse
MGI:2675387
244551
Rat
RGD:1306672
288909
Dog
nanos C2HC-type zinc finger 3 [Source:HGNC Symbol;Acc:HGNC:22048]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nanos C2HC-type zinc finger 3
Macaque
nanos C2HC-type zinc finger 3
Mouse
Rat
Dog
nanos C2HC-type zinc finger 3 [Source:HGNC Symbol;Acc:HGNC:22048]
Publication Statistics
PubMed Score 54.70
PubMed score by year
PubTator Score 11.03
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title