Tbio NANOS2 Nanos homolog 2

Protein Summary

Description

Plays a key role in the sexual differentiation of germ cells by promoting the male fate but suppressing the female fate. Represses the female fate pathways by suppressing meiosis, which in turn results in the promotion of the male fate. Maintains the suppression of meiosis by preventing STRA8 expression, which is required for premeiotic DNA replication, after CYP26B1 is decreased. Regulates the localization of the CCR4-NOT deadenylation complex to P-bodies and plays a role in recruiting the complex to trigger the degradation of mRNAs involved in meiosis. Required for the maintenance of the spermatogonial stem cell population. Not essential for the assembly of P-bodies but is required for the maintenance of their normal state (By similarity).

Uniprot Accession IDs

• P60321
• Q17R30
• Q4G0P8
• NOS-2

Gene Name

• NANOS2

Ensembl ID

• ENST00000341294
• ENSP00000341021
• ENSG00000188425

Symbol

• NOS2
• NOS2
• ZC2HC12B

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.79
cell type or tissue	0.63
tissue	0.58
cell line	0.57
molecular function	0.49

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Nuclease / Nanos Homolog 2

DTO Classes

Protein / Enzyme / Nuclease / Nanos Homolog 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.36   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 240   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.36   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 240   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

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No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (73)

Explore Interacting Targets

1 – 10 of 73

• See Interactions on String-DB

CNOT6

Tbio

Novelty:  0.03605299

p_int:  0.999999957

p_ni:  4.3e-8

Score:  0.784

Data Source:  BioPlex,STRINGDB

CNOT6L

Tbio

Novelty:  0.06038336

p_int:  0.999999898

p_ni:  1.02e-7

Score:  0.84

Data Source:  BioPlex,STRINGDB

CNOT2

Tbio

Novelty:  0.01886737

p_int:  0.999999273

p_ni:  7.27e-7

Score:  0.81

Data Source:  BioPlex,STRINGDB

TOB2

Tbio

Novelty:  0.02809091

p_int:  0.999999206

p_ni:  9.7e-8

p_wrong:  6.97e-7

Score:  0.69

Data Source:  BioPlex,STRINGDB

TNKS1BP1

Tbio

Family:  Enzyme

Novelty:  0.21682007

p_int:  0.999998343

p_ni:  0.000001657

Score:  0.588

Data Source:  BioPlex,STRINGDB

BTG3

Tbio

Novelty:  0.01541026

p_int:  0.99999788

p_ni:  0.00000212

Score:  0.687

Data Source:  BioPlex,STRINGDB

CNOT11

Tbio

Novelty:  0.01687183

p_int:  0.999996879

p_ni:  0.000003121

Score:  0.873

Data Source:  BioPlex,STRINGDB

CNOT10

Tdark

Novelty:  0.30195594

p_int:  0.999995824

p_ni:  0.000004176

Score:  0.732

Data Source:  BioPlex,STRINGDB

CNOT3

Tbio

Novelty:  0.02463568

p_int:  0.999995548

p_ni:  0.000004452

Score:  0.756

Data Source:  BioPlex,STRINGDB

MINK1

Tchem

Family:  Kinase

Novelty:  0.00505208

p_int:  0.999994834

p_ni:  0.000004268

p_wrong:  8.98e-7

Score:  0.189

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (14)

Functions (2)

Components (4)

Processes (8)

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GO Term	Evidence	Assigned by
mRNA binding	Inferred from Electronic Annotation (IEA)	Ensembl
zinc ion binding	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations (null)

No disease associations found

GWAS Traits (19)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 19

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
eosinophil count	EFO_0004842	2	3	3		90.4
testosterone measurement	EFO_0004908	3	3	3		88.4
apolipoprotein B measurement	EFO_0004615	1	2	2		86.8
eosinophil percentage of leukocytes	EFO_0007991	1	2	2		85.3
low density lipoprotein cholesterol measurement	EFO_0004611	2	2	2		84.9

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 19

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
eosinophil count	EFO_0004842	3		90.4
testosterone measurement	EFO_0004908	3		88.4
apolipoprotein B measurement	EFO_0004615	2		86.8
eosinophil percentage of leukocytes	EFO_0007991	2		85.3
low density lipoprotein cholesterol measurement	EFO_0004611	2		84.9

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UniProt Keyword Find Similar Targets

No Header	No Header
Complete proteome
Cytoplasm
Developmental protein
Differentiation
Metal-binding
Polymorphism
Reference proteome
RNA-binding
Spermatogenesis
Translation regulation

GWAS Trait Find Similar Targets

No Header	No Header
apolipoprotein A 1 measurement
apolipoprotein B measurement
asthma
C-reactive protein measurement
colonic neoplasm
coronary artery disease
electrocardiography
eosinophil count
eosinophil percentage of leukocytes
gallstones

MGI Phenotype Find Similar Targets

No Header	No Header
cellular phenotype
endocrine/exocrine gland phenotype
reproductive system phenotype

IDG Resources

No IDG generated resources found

Orthologs (8)

1 – 5 of 8

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	nanos C2HC-type zinc finger 2	VGNC:11190	745748
Macaque	nanos C2HC-type zinc finger 2		715753
Mouse	nanos C2HC-type zinc finger 2	MGI:2676627	378430
Rat	nanos C2HC-type zinc finger 2	RGD:1562436	365213
Dog	nanos C2HC-type zinc finger 2	VGNC:43614	484432

Species	Name	OMA	EggNOG	Inparanoid
Chimp	nanos C2HC-type zinc finger 2
Macaque	nanos C2HC-type zinc finger 2
Mouse	nanos C2HC-type zinc finger 2
Rat	nanos C2HC-type zinc finger 2
Dog	nanos C2HC-type zinc finger 2

Publication Statistics

PubMed Score 77.36

PubMed score by year

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PubTator Score 11.51

PubTator score by year

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Related Publications

Text Mined References (10)

GeneRif Annotations (3)

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10

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PMID	Year	Title