Protein Summary
Plays a key role in the sexual differentiation of germ cells by promoting the male fate but suppressing the female fate. Represses the female fate pathways by suppressing meiosis, which in turn results in the promotion of the male fate. Maintains the suppression of meiosis by preventing STRA8 expression, which is required for premeiotic DNA replication, after CYP26B1 is decreased. Regulates the localization of the CCR4-NOT deadenylation complex to P-bodies and plays a role in recruiting the complex to trigger the degradation of mRNAs involved in meiosis. Required for the maintenance of the spermatogonial stem cell population. Not essential for the assembly of P-bodies but is required for the maintenance of their normal state (By similarity).
- ENST00000341294
- ENSP00000341021
- ENSG00000188425
- NOS2
- NOS2
- ZC2HC12B
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological process | 0.79 | ||
cell type or tissue | 0.63 | ||
tissue | 0.58 | ||
cell line | 0.57 | ||
molecular function | 0.49 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 77.36 (req: < 5)
Gene RIFs: 3 (req: <= 3)
Antibodies: 240 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 77.36 (req: >= 5)
Gene RIFs: 3 (req: > 3)
Antibodies: 240 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (73)
CNOT6
Novelty: 0.03605299
p_int: 0.999999957
p_ni: 4.3e-8
Score: 0.784
Data Source: BioPlex,STRINGDB
CNOT6L
Novelty: 0.06038336
p_int: 0.999999898
p_ni: 1.02e-7
Score: 0.84
Data Source: BioPlex,STRINGDB
CNOT2
Novelty: 0.01886737
p_int: 0.999999273
p_ni: 7.27e-7
Score: 0.81
Data Source: BioPlex,STRINGDB
TOB2
Novelty: 0.02809091
p_int: 0.999999206
p_ni: 9.7e-8
p_wrong: 6.97e-7
Score: 0.69
Data Source: BioPlex,STRINGDB
TNKS1BP1
Family: Enzyme
Novelty: 0.21682007
p_int: 0.999998343
p_ni: 0.000001657
Score: 0.588
Data Source: BioPlex,STRINGDB
BTG3
Novelty: 0.01541026
p_int: 0.99999788
p_ni: 0.00000212
Score: 0.687
Data Source: BioPlex,STRINGDB
CNOT11
Novelty: 0.01687183
p_int: 0.999996879
p_ni: 0.000003121
Score: 0.873
Data Source: BioPlex,STRINGDB
CNOT10
Novelty: 0.30195594
p_int: 0.999995824
p_ni: 0.000004176
Score: 0.732
Data Source: BioPlex,STRINGDB
CNOT3
Novelty: 0.02463568
p_int: 0.999995548
p_ni: 0.000004452
Score: 0.756
Data Source: BioPlex,STRINGDB
MINK1
Family: Kinase
Novelty: 0.00505208
p_int: 0.999994834
p_ni: 0.000004268
p_wrong: 8.98e-7
Score: 0.189
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (14)
Functions (2)
Components (4)
Processes (8)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (19)
Items per page:
1 – 5 of 19
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
eosinophil count | 2 | 3 | 3 | 90.4 | |||||
testosterone measurement | 3 | 3 | 3 | 88.4 | |||||
apolipoprotein B measurement | 1 | 2 | 2 | 86.8 | |||||
eosinophil percentage of leukocytes | 1 | 2 | 2 | 85.3 | |||||
low density lipoprotein cholesterol measurement | 2 | 2 | 2 | 84.9 | |||||
Items per page:
1 – 5 of 19
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
eosinophil count | 3 | 90.4 | |||||
testosterone measurement | 3 | 88.4 | |||||
apolipoprotein B measurement | 2 | 86.8 | |||||
eosinophil percentage of leukocytes | 2 | 85.3 | |||||
low density lipoprotein cholesterol measurement | 2 | 84.9 | |||||
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | nanos C2HC-type zinc finger 2 | VGNC:11190 | 745748 | |||||
Macaque | nanos C2HC-type zinc finger 2 | 715753 | ||||||
Mouse | MGI:2676627 | 378430 | ||||||
Rat | RGD:1562436 | 365213 | ||||||
Dog | nanos C2HC-type zinc finger 2 | VGNC:43614 | 484432 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | nanos C2HC-type zinc finger 2 | |||||
Macaque | nanos C2HC-type zinc finger 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | nanos C2HC-type zinc finger 2 | |||||
Publication Statistics
PubMed Score 77.36
PubMed score by year
PubTator Score 11.51
PubTator score by year
Related Publications
Text Mined References (10)
GeneRif Annotations (3)
Items per page:
0 of 0
PMID | Year | Title |
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