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Tbio
NANOS2
Nanos homolog 2

Protein Summary
Description
Plays a key role in the sexual differentiation of germ cells by promoting the male fate but suppressing the female fate. Represses the female fate pathways by suppressing meiosis, which in turn results in the promotion of the male fate. Maintains the suppression of meiosis by preventing STRA8 expression, which is required for premeiotic DNA replication, after CYP26B1 is decreased. Regulates the localization of the CCR4-NOT deadenylation complex to P-bodies and plays a role in recruiting the complex to trigger the degradation of mRNAs involved in meiosis. Required for the maintenance of the spermatogonial stem cell population. Not essential for the assembly of P-bodies but is required for the maintenance of their normal state (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000341294
  • ENSP00000341021
  • ENSG00000188425

Symbol
  • NOS2
  • NOS2
  • ZC2HC12B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.79
cell type or tissue
0.63
tissue
0.58
cell line
0.57
molecular function
0.49


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.36   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 240   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.36   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 240   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (73)
CNOT6
Tbio
Novelty:  0.03605299
p_int:  0.999999957
p_ni:  4.3e-8
Score:  0.784
Data Source:  BioPlex,STRINGDB
CNOT6L
Tbio
Novelty:  0.06038336
p_int:  0.999999898
p_ni:  1.02e-7
Score:  0.84
Data Source:  BioPlex,STRINGDB
CNOT2
Tbio
Novelty:  0.01886737
p_int:  0.999999273
p_ni:  7.27e-7
Score:  0.81
Data Source:  BioPlex,STRINGDB
TOB2
Tbio
Novelty:  0.02809091
p_int:  0.999999206
p_ni:  9.7e-8
p_wrong:  6.97e-7
Score:  0.69
Data Source:  BioPlex,STRINGDB
TNKS1BP1
Tbio
Family:  Enzyme
Novelty:  0.21682007
p_int:  0.999998343
p_ni:  0.000001657
Score:  0.588
Data Source:  BioPlex,STRINGDB
BTG3
Tbio
Novelty:  0.01541026
p_int:  0.99999788
p_ni:  0.00000212
Score:  0.687
Data Source:  BioPlex,STRINGDB
CNOT11
Tbio
Novelty:  0.01687183
p_int:  0.999996879
p_ni:  0.000003121
Score:  0.873
Data Source:  BioPlex,STRINGDB
CNOT10
Tdark
Novelty:  0.30195594
p_int:  0.999995824
p_ni:  0.000004176
Score:  0.732
Data Source:  BioPlex,STRINGDB
CNOT3
Tbio
Novelty:  0.02463568
p_int:  0.999995548
p_ni:  0.000004452
Score:  0.756
Data Source:  BioPlex,STRINGDB
MINK1
Tchem
Family:  Kinase
Novelty:  0.00505208
p_int:  0.999994834
p_ni:  0.000004268
p_wrong:  8.98e-7
Score:  0.189
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (14)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
2
3
3
90.4
testosterone measurement
3
3
3
88.4
apolipoprotein B measurement
1
2
2
86.8
eosinophil percentage of leukocytes
1
2
2
85.3
low density lipoprotein cholesterol measurement
2
2
2
84.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
90.4
testosterone measurement
3
88.4
apolipoprotein B measurement
2
86.8
eosinophil percentage of leukocytes
2
85.3
low density lipoprotein cholesterol measurement
2
84.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nanos C2HC-type zinc finger 2
VGNC:11190
745748
Macaque
nanos C2HC-type zinc finger 2
715753
Mouse
MGI:2676627
378430
Rat
RGD:1562436
365213
Dog
nanos C2HC-type zinc finger 2
VGNC:43614
484432
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nanos C2HC-type zinc finger 2
Macaque
nanos C2HC-type zinc finger 2
Mouse
Rat
Dog
nanos C2HC-type zinc finger 2
Publication Statistics
PubMed Score 77.36
PubMed score by year
PubTator Score 11.51
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title