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Tchem
NAMPT
Nicotinamide phosphoribosyltransferase

Protein Summary
Description
Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-ARNTL/BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression (By similarity). This gene encodes a protein that catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, one step in the biosynthesis of nicotinamide adenine dinuc ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000222553
  • ENSP00000222553
  • ENSG00000105835

Symbol
  • PBEF
  • PBEF1
  • VF
  • PBEF
  • PBEF1
  • VISFATIN
  • 1110035O14Rik
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
transcription factor perturbation
0.98
virus perturbation
0.97
transcription factor binding site profile
0.86
biological process
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1442.8   (req: < 5)
Gene RIFs: 425   (req: <= 3)
Antibodies: 885   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1442.8   (req: >= 5)
Gene RIFs: 425   (req: > 3)
Antibodies: 885   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2146
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (2146)
CHEMBL4170617
Rendered image for CHEMBL4170617
CHEMBL4163681
Rendered image for CHEMBL4163681
CHEMBL17289
Rendered image for CHEMBL17289
CHEMBL4065412
Rendered image for CHEMBL4065412
CHEMBL3127501
Rendered image for CHEMBL3127501
CHEMBL3127521
Rendered image for CHEMBL3127521
CHEMBL3127520
Rendered image for CHEMBL3127520
CHEMBL3127500
Rendered image for CHEMBL3127500
CHEMBL3127510
Rendered image for CHEMBL3127510
CHEMBL3127506
Rendered image for CHEMBL3127506
Protein-Protein Interactions (148)
LGALS7
Tbio
Novelty:  0.00753996
p_int:  0.99185746
p_ni:  0.00814254
Score:  0.169
Data Source:  BioPlex,STRINGDB
TMEM25
Tdark
Novelty:  0.35505784
p_int:  0.958877994
p_ni:  0.041122006
Score:  0.159
Data Source:  BioPlex,STRINGDB
IL13RA2
Tbio
Novelty:  0.03465642
p_int:  0.931216274
p_ni:  0.068783726
Data Source:  BioPlex
MAPK15
Tchem
Family:  Kinase
Novelty:  0.02414054
p_int:  0.899314463
p_ni:  0.100685537
Score:  0.329
Data Source:  BioPlex,STRINGDB
C16orf71
Tdark
Novelty:  0.97826087
p_int:  0.835208243
p_ni:  0.164791757
Score:  0.165
Data Source:  BioPlex,STRINGDB
NMNAT1
Tbio
Family:  Enzyme
Novelty:  0.01110899
Score:  0.979
Data Source:  STRINGDB
CLOCK
Tbio
Family:  TF; Epigenetic
Novelty:  0.00159625
Score:  0.978
Data Source:  STRINGDB
NMNAT3
Tbio
Family:  Enzyme
Novelty:  0.03261313
Score:  0.971
Data Source:  STRINGDB
ARNTL
Tbio
Family:  TF
Novelty:  0.00102829
Score:  0.969
Data Source:  STRINGDB
NMNAT2
Tbio
Family:  Enzyme
Novelty:  0.01709189
Score:  0.966
Data Source:  STRINGDB
Pathways (54)
BMAL1:CLOCK,NPAS2 activates circadian gene expression (R-HSA-1368108)

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Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
BMAL1:CLOCK,NPAS2 activates circadian gene expression
Reactome
Circadian Clock
Reactome
Metabolism
Reactome
Metabolism of vitamins and cofactors
Reactome
Metabolism of water-soluble vitamins and cofactors
Name
Explore in Pharos
Explore in Source
BMAL1:CLOCK,NPAS2 activates circadian gene expression
Circadian Clock
Metabolism
Metabolism of vitamins and cofactors
Metabolism of water-soluble vitamins and cofactors
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (32)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
creatinine measurement
1
1
1
6.6
glomerular filtration rate
1
1
1
5.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
creatinine measurement
1
6.6
glomerular filtration rate
1
5.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
nicotinamide phosphoribosyltransferase
698609
Mouse
MGI:1929865
59027
Rat
RGD:631365
297508
Dog
nicotinamide phosphoribosyltransferase
VGNC:49876
100856598
Horse
nicotinamide phosphoribosyltransferase
VGNC:20554
100059684
Species
Name
OMA
EggNOG
Inparanoid
Macaque
nicotinamide phosphoribosyltransferase
Mouse
Rat
Dog
nicotinamide phosphoribosyltransferase
Horse
nicotinamide phosphoribosyltransferase
Publication Statistics
PubMed Score 1442.80
PubMed score by year
PubTator Score 1095.52
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title