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Tbio
NAGPA
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase

Protein Summary
Description
Catalyzes the second step in the formation of the mannose 6-phosphate targeting signal on lysosomal enzyme oligosaccharides by removing GlcNAc residues from GlcNAc-alpha-P-mannose moieties, which are formed in the first step. Also hydrolyzes UDP-GlcNAc, a sugar donor for Golgi N-acetylglucosaminyltransferases. Hydrolases are transported to lysosomes after binding to mannose 6-phosphate receptors in the trans-Golgi network. This gene encodes the enzyme that catalyzes the second step in the formation of the mannose 6-phosphate recognition marker on lysosomal hydrolases. Commonly known as 'uncovering enzyme' or UCE, this enzyme removes N-acetyl-D-glucosamine (GlcNAc) residues from GlcNAc-alpha-P-mannose moieties and thereby produces the recognition marker. The encoded preproprotein is proteolytically processed by furin to generate the mature enzyme, a homotetramer of two disulfide-linked homodimers. Mutations in this gene are associated with developmental stuttering in human patients. [pr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000312251
  • ENSP00000310998
  • ENSG00000103174
  • ENST00000381955
  • ENSP00000371381
  • ENST00000562746
  • ENSP00000455900
  • ENST00000649828
  • ENSP00000498032

Symbol
  • UCE
  • APAA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.88
kinase perturbation
0.84
disease perturbation
0.74
transcription factor binding site profile
0.73
cellular component
0.6


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.72   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 34   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.72   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 34   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (57)
NGLY1
Tbio
Family:  Enzyme
Novelty:  0.01017395
p_int:  0.994181736
p_ni:  0.005818264
Score:  0.221
Data Source:  BioPlex,STRINGDB
TYW3
Tdark
Novelty:  0.15183348
p_int:  0.994055245
p_ni:  0.00594084
p_wrong:  0.000003915
Data Source:  BioPlex
FADS3
Tbio
Family:  Enzyme
Novelty:  0.02899077
p_int:  0.981643709
p_ni:  0.018356144
p_wrong:  1.47e-7
Score:  0.175
Data Source:  BioPlex,STRINGDB
FSHR
Tclin
Family:  GPCR
Novelty:  0.00123929
p_int:  0.961821461
p_ni:  0.037729931
p_wrong:  0.000448608
Score:  0.179
Data Source:  BioPlex,STRINGDB
UBR3
Tbio
Family:  Enzyme
Novelty:  0.14930754
p_int:  0.953316232
p_ni:  0.046683768
Data Source:  BioPlex
SLAMF7
Tclin
Novelty:  0.01014396
p_int:  0.952203956
p_ni:  0.047796044
Score:  0.295
Data Source:  BioPlex,STRINGDB
ABCD4
Tbio
Family:  Transporter
Novelty:  0.04096359
p_int:  0.93779349
p_ni:  0.061200411
p_wrong:  0.001006098
Data Source:  BioPlex
AP2M1
Tbio
Novelty:  0.00769368
p_int:  0.863775085
p_ni:  0.136224849
p_wrong:  6.7e-8
Data Source:  BioPlex
ADGRE5
Tbio
Family:  GPCR
Novelty:  0.01137558
p_int:  0.797029268
p_ni:  0.20297055
p_wrong:  1.82e-7
Data Source:  BioPlex
WDR54
Tdark
Novelty:  1.19807122
p_int:  0.788562343
p_ni:  0.211437656
p_wrong:  1e-9
Score:  0.185
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
2
3
93.7
platelet count
1
1
1
37.6
1
1
0
11.7
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
93.7
platelet count
1
37.6
0
11.7
30.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
VGNC:9009
453894
Macaque
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
707352
Mouse
MGI:1351598
27426
Rat
RGD:1308972
360476
Dog
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
VGNC:43610
490019
Species
Name
OMA
EggNOG
Inparanoid
Chimp
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
Macaque
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
Mouse
Rat
Dog
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
Publication Statistics
PubMed Score 33.72
PubMed score by year
PubTator Score 27.45
PubTator score by year
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Related Publications
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PMID
Year
Title