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Tbio
NAGK
N-acetyl-D-glucosamine kinase

Protein Summary
Description
Converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway: although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded. Also has ManNAc kinase activity. This gene encodes a member of the N-acetylhexosamine kinase family. The encoded protein catalyzes the conversion of N-acetyl-D-glucosamine to N-acetyl-D-glucosamine 6-phosphate, and is the major mammalian enzyme which recovers amino sugars. [provided by RefSeq, Nov 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000244204
  • ENSP00000244204
  • ENSG00000124357
  • ENST00000455662
  • ENSP00000389087
  • ENST00000613852
  • ENSP00000477639

Symbol
  • GNK
  • HSA242910
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.95
molecular function
0.93
transcription factor perturbation
0.84
transcription factor binding site profile
0.83
disease perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.39   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 279   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.39   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 279   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (88)
ZBTB43
Tdark
Family:  TF
Novelty:  0.35735342
p_int:  0.99999985
p_ni:  1.04e-7
p_wrong:  4.6e-8
Score:  0.161
Data Source:  BioPlex,STRINGDB
RAI1
Tbio
Family:  Epigenetic
Novelty:  0.01088494
p_int:  0.999999741
p_ni:  3.5e-8
p_wrong:  2.25e-7
Score:  0.356
Data Source:  BioPlex,STRINGDB
HOXB6
Tbio
Family:  TF
Novelty:  0.0176813
p_int:  0.999997302
p_ni:  4.14e-7
p_wrong:  0.000002284
Score:  0.189
Data Source:  BioPlex,STRINGDB
RBM6
Tbio
Novelty:  0.06349982
p_int:  0.999996294
p_ni:  0.000003705
p_wrong:  1e-9
Score:  0.234
Data Source:  BioPlex,STRINGDB
SCAF8
Tbio
Novelty:  0.1650699
p_int:  0.999988614
p_ni:  0.000011386
Score:  0.181
Data Source:  BioPlex,STRINGDB
ZIC2
Tbio
Family:  TF
Novelty:  0.00900257
p_int:  0.999969558
p_ni:  0.000004537
p_wrong:  0.000025905
Score:  0.186
Data Source:  BioPlex,STRINGDB
HNRNPH1
Tbio
Novelty:  0.01273351
p_int:  0.998952295
p_ni:  0.001047705
Score:  0.186
Data Source:  BioPlex,STRINGDB
EVA1B
Tdark
Novelty:  2.1380272
p_int:  0.99876885
p_ni:  0.001231149
p_wrong:  1e-9
Data Source:  BioPlex
XRN1
Tbio
Family:  Enzyme
Novelty:  0.00409381
p_int:  0.998429126
p_ni:  0.001551415
p_wrong:  0.000019459
Score:  0.181
Data Source:  BioPlex,STRINGDB
C2CD5
Tbio
Novelty:  0.40144687
p_int:  0.997133095
p_ni:  0.002866891
p_wrong:  1.5e-8
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Synthesis of UDP-N-acetyl-glucosamine
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Metabolism of proteins
Post-translational protein modification
Synthesis of UDP-N-acetyl-glucosamine
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
2
1
2
21.4
eosinophil percentage of leukocytes
1
1
1
13.8
intelligence
1
1
0
5.6
0.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
2
21.4
eosinophil percentage of leukocytes
1
13.8
intelligence
0
5.6
0.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
N-acetylglucosamine kinase
VGNC:304
459309
Macaque
N-acetylglucosamine kinase
703976
Mouse
MGI:1860418
56174
Rat
RGD:1305057
297393
Horse
N-acetylglucosamine kinase
VGNC:20548
100050213
Species
Name
OMA
EggNOG
Inparanoid
Chimp
N-acetylglucosamine kinase
Macaque
N-acetylglucosamine kinase
Mouse
Rat
Horse
N-acetylglucosamine kinase
Publication Statistics
PubMed Score 63.39
PubMed score by year
PubTator Score 24.60
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title