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Tbio
NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

Protein Summary
Description
RNA-binding protein required for the maturation of box H/ACA snoRNPs complex and ribosome biogenesis. During assembly of the H/ACA snoRNPs complex, it associates with the complex and disappears during maturation of the complex and is replaced by NOLA1/GAR1 to yield mature H/ACA snoRNPs complex. Probably competes with NOLA1/GAR1 for binding with DKC1/NOLA4.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000274054
  • ENSP00000274054
  • ENSG00000145414
  • ENST00000422287
  • ENSP00000408963
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.8
tissue sample
0.64
cell line
0.54
transcription factor perturbation
0.54
histone modification site profile
0.53


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.28   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 38   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.28   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 38   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (115)
DKC1
Tbio
Novelty:  0.00352181
p_int:  0.999996789
p_ni:  0.000003211
Score:  0.992
Data Source:  BioPlex,STRINGDB
BCHE
Tclin
Family:  Enzyme
Novelty:  0.00031267
p_int:  0.999994728
p_ni:  0.000005232
p_wrong:  4e-8
Score:  0.213
Data Source:  BioPlex,STRINGDB
PIP4K2A
Tbio
Family:  Kinase
Novelty:  0.01130885
p_int:  0.999992123
p_ni:  0.000007876
p_wrong:  1e-9
Data Source:  BioPlex
FAM9A
Tdark
Novelty:  0.72563725
p_int:  0.999991125
p_ni:  0.000008814
p_wrong:  6.1e-8
Score:  0.204
Data Source:  BioPlex,STRINGDB
PES1
Tbio
Novelty:  0.07162845
p_int:  0.999919253
p_ni:  0.000078722
p_wrong:  0.000002024
Score:  0.856
Data Source:  BioPlex,STRINGDB
MDK
Tchem
Novelty:  0.00145301
p_int:  0.99986756
p_ni:  0.000132437
p_wrong:  4e-9
Score:  0.213
Data Source:  BioPlex,STRINGDB
EPB41L5
Tbio
Novelty:  0.0391959
p_int:  0.999841648
p_ni:  0.000158063
p_wrong:  2.88e-7
Score:  0.649
Data Source:  BioPlex,STRINGDB
EPB41L1
Tbio
Novelty:  0.02937451
p_int:  0.999838599
p_ni:  0.000074961
p_wrong:  0.00008644
Data Source:  BioPlex
EPB41L3
Tbio
Novelty:  0.00915217
p_int:  0.999776484
p_ni:  0.000223399
p_wrong:  1.17e-7
Data Source:  BioPlex
EDA
Tbio
Novelty:  0.00352464
p_int:  0.99892552
p_ni:  0.001074476
p_wrong:  4e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
telomere length
2
2
3
75.3
response to exercise
1
1
1
1.3
TPE interval measurement
1
1
1
1.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
telomere length
3
75.3
response to exercise
1
1.3
TPE interval measurement
1
1.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nuclear assembly factor 1 ribonucleoprotein
VGNC:749
461581
Macaque
nuclear assembly factor 1 ribonucleoprotein
702745
Mouse
MGI:2682306
234344
Rat
RGD:1306802
306387
Pig
nuclear assembly factor 1 ribonucleoprotein
100518673
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nuclear assembly factor 1 ribonucleoprotein
Macaque
nuclear assembly factor 1 ribonucleoprotein
Mouse
Rat
Pig
nuclear assembly factor 1 ribonucleoprotein
Publication Statistics
PubMed Score 0.28
PubMed score by year
PubTator Score 22.13
PubTator score by year
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Related Publications
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PMID
Year
Title