Tchem NAE1 NEDD8-activating enzyme E1 regulatory subunit

Protein Summary

Description

Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation. The protein encoded by this gene binds to the beta-amyloid precursor protein. Beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. In addition, the encoded protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. This protein is required for cell cycle progression through the S/M checkpoint. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q13564
• A6NCK0
• A6NFN4
• A8MU28
• B2R700
• B3KUP9

Gene Name

• NAE1

Ensembl ID

• ENST00000290810
• ENSP00000290810
• ENSG00000159593
• ENST00000359087
• ENSP00000351990
• ENST00000379463
• ENSP00000368776
• ENST00000394074
• ENSP00000377637

Symbol

• APPBP1
• HPP1
• ula-1
• APPBP1
• A-116A10.1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.9
co-expressed gene	0.89
kinase perturbation	0.88
transcription factor binding site profile	0.8
gene perturbation	0.78

Protein Classes

PANTHER Classes

Protein / Transfer/carrier Protein / Nedd8-activating Enzyme E1 Regulatory Subunit

Protein / Ligase / Nedd8-activating Enzyme E1 Regulatory Subunit

DTO Classes

Protein / Enzyme / Ligase / Nedd8-activating Enzyme E1 Regulatory Subunit

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.45   (req: < 5)

Gene RIFs: 13   (req: <= 3)

Antibodies: 362   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.45   (req: >= 5)

Gene RIFs: 13   (req: > 3)

Antibodies: 362   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0