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Tbio
NADK2
NAD kinase 2, mitochondrial

Protein Summary
Description
Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor. Also has weak NADH kinase activity in vitro; however NADH kinase activity is much weaker than the NAD(+) kinase activity and may not be relevant in vivo. This gene encodes a mitochondrial kinase that catalyzes the phosphorylation of NAD to yield NADP. Mutations in this gene result in 2,4-dienoyl-CoA reductase deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000282512
  • ENSP00000282512
  • ENSG00000152620
  • ENST00000381937
  • ENSP00000371362
  • ENST00000397338
  • ENSP00000380499
  • ENST00000514504
  • ENSP00000421029

Symbol
  • C5orf33
  • MNADK
  • NADKD1
  • DECRD
  • MNADK
  • NADKD1
  • C5orf33
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.94
transcription factor perturbation
0.88
protein domain
0.73
histone modification site profile
0.72
cell type or tissue
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.16   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 146   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.16   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 146   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (27)
ETFRF1
Tdark
Novelty:  1.28847105
p_int:  0.936142663
p_ni:  0.063857337
Score:  0.359
Data Source:  BioPlex,STRINGDB
NADK
Tbio
Family:  Kinase
Novelty:  0.02812925
Score:  0.979
Data Source:  STRINGDB
NNT
Tbio
Family:  Enzyme
Novelty:  0.00269343
Score:  0.938
Data Source:  STRINGDB
NMNAT3
Tbio
Family:  Enzyme
Novelty:  0.03261313
Score:  0.938
Data Source:  STRINGDB
NADSYN1
Tbio
Family:  Enzyme
Novelty:  0.0445844
Score:  0.937
Data Source:  STRINGDB
NMNAT1
Tbio
Family:  Enzyme
Novelty:  0.01110899
Score:  0.931
Data Source:  STRINGDB
NMNAT2
Tbio
Family:  Enzyme
Novelty:  0.01709189
Score:  0.913
Data Source:  STRINGDB
NUDT12
Tbio
Family:  Enzyme
Novelty:  0.18740719
Score:  0.902
Data Source:  STRINGDB
ENPP3
Tchem
Family:  Enzyme
Novelty:  0.00414129
Score:  0.901
Data Source:  STRINGDB
BST1
Tbio
Family:  Enzyme
Novelty:  0.01329061
Score:  0.9
Data Source:  STRINGDB
Pathways (6)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of vitamins and cofactors
Reactome
Metabolism of water-soluble vitamins and cofactors
Reactome
Nicotinate metabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of vitamins and cofactors
Metabolism of water-soluble vitamins and cofactors
Nicotinate metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
2
4
88.2
mean corpuscular volume
1
1
1
64.4
mean reticulocyte volume
1
1
1
59.9
mean corpuscular hemoglobin concentration
1
1
1
54.4
1
1
0
1.1
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
88.2
mean corpuscular volume
1
64.4
mean reticulocyte volume
1
59.9
mean corpuscular hemoglobin concentration
1
54.4
0
1.1
31.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NAD kinase 2, mitochondrial
VGNC:7089
461919
Macaque
NAD kinase 2, mitochondrial
704285
Mouse
MGI:1915896
68646
Rat
RGD:1306809
365699
Horse
NAD kinase 2, mitochondrial
VGNC:20544
100067696
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NAD kinase 2, mitochondrial
Macaque
NAD kinase 2, mitochondrial
Mouse
Rat
Horse
NAD kinase 2, mitochondrial
Publication Statistics
PubMed Score 13.16
PubMed score by year
PubTator Score 3.92
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title