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Tdark
NACAD
NAC-alpha domain-containing protein 1

Protein Summary
Description
May prevent inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). May bind to nascent polypeptide chains as they emerge from the ribosome and block their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. May also reduce the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites) (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000490531
  • ENSP00000420477
  • ENSG00000136274

Symbol
  • KIAA0363
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.66
tissue sample
0.61
cell line
0.48
protein complex
0.41
co-expressed gene
0.4


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.32   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 70   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.32   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 70   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (82)
BTF3
Tbio
Novelty:  0.01198537
p_int:  0.999999995
p_ni:  5e-9
Score:  0.895
Data Source:  BioPlex,STRINGDB
VAPB
Tbio
Novelty:  0.00542377
p_int:  0.999999933
p_ni:  4.1e-8
p_wrong:  2.7e-8
Score:  0.251
Data Source:  BioPlex,STRINGDB
BTF3L4
Tdark
Novelty:  0.61724061
p_int:  0.999999906
p_ni:  2.2e-8
p_wrong:  7.2e-8
Score:  0.895
Data Source:  BioPlex,STRINGDB
VAPA
Tbio
Novelty:  0.00169209
p_int:  0.999999797
p_ni:  1.85e-7
p_wrong:  1.8e-8
Score:  0.441
Data Source:  BioPlex,STRINGDB
EPB41L3
Tbio
Novelty:  0.00915217
p_int:  0.999999425
p_ni:  2.84e-7
p_wrong:  2.91e-7
Data Source:  BioPlex
WDR53
Tdark
Novelty:  0.9750546
p_int:  0.852033927
p_ni:  0.000008259
p_wrong:  0.147957814
Score:  0.379
Data Source:  BioPlex,STRINGDB
RPL35
Tbio
Novelty:  0.03722634
Score:  0.755
Data Source:  STRINGDB
RPL4
Tbio
Novelty:  0.00475169
Score:  0.713
Data Source:  STRINGDB
P62861
Tbio
Novelty:  0.01170009
Score:  0.699
Data Source:  STRINGDB
P35544
Tbio
Novelty:  0.01170009
Score:  0.699
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil percentage of leukocytes
1
1
1
53.3
platelet crit
1
1
1
30.2
eosinophil count
2
1
2
29.9
smoking status measurement
1
1
1
26.6
1
1
1
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil percentage of leukocytes
1
53.3
platelet crit
1
30.2
eosinophil count
2
29.9
smoking status measurement
1
26.6
1
15.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NAC alpha domain containing
VGNC:4440
463390
Mouse
MGI:3603030
192950
Rat
RGD:1559824
289786
Cow
NAC alpha domain containing
VGNC:53662
531208
Pig
NAC alpha domain containing
100511728
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NAC alpha domain containing
Mouse
Rat
Cow
NAC alpha domain containing
Pig
NAC alpha domain containing
Publication Statistics
PubMed Score 2.32
PubMed score by year
PubTator Score 1.50
PubTator score by year
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Related Publications
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PMID
Year
Title