Tbio NABP2 SOSS complex subunit B1

Protein Summary

Description

Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. Single-stranded DNA (ssDNA)-binding proteins, such as OBFC2B, are ubiquitous and essential for a variety of DNA metabolic processes, including replication, recombination, and detection and repair of damage (Richard et al., 2008 [PubMed 18449195]).[supplied by OMIM, Jun 2008]

Uniprot Accession IDs

• Q9BQ15
• A6NDF8
• Q6XYC8

Gene Name

• NABP2

Ensembl ID

• ENST00000267023
• ENSP00000267023
• ENSG00000139579
• ENST00000341463
• ENSP00000368862
• ENST00000380198
• ENSP00000369545

Symbol

• OBFC2B
• SSB1
• SSB1
• hSSB1
• OBFC2B
• SOSS-B1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
phenotype	0.86
cell type or tissue	0.83
transcription factor binding site profile	0.74
transcription factor perturbation	0.74
transcription factor	0.71

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Soss Complex Subunit B1

DTO Classes

Protein / Nucleic Acid Binding / Soss Complex Subunit B1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.25   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 116   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.25   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 116   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Show Full Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (118)

Explore Interacting Targets

1 – 10 of 118

• See Interactions on String-DB

INIP

Tbio

Novelty:  0.08511211

p_int:  0.999999996

p_ni:  3e-9

p_wrong:  1e-9

Score:  0.999

Data Source:  BioPlex,STRINGDB

INTS3

Tbio

Novelty:  0.13398603

p_int:  0.999999848

p_ni:  1.52e-7

Score:  0.999

Data Source:  BioPlex,STRINGDB

INTS6L

Tdark

Novelty:  1.91229606

p_int:  0.999999772

p_ni:  2.05e-7

p_wrong:  2.2e-8

Data Source:  BioPlex

INTS9

Tbio

Novelty:  0.06037786

p_int:  0.999998125

p_ni:  0.000001874

p_wrong:  1e-9

Score:  0.945

Data Source:  BioPlex,STRINGDB

INTS6

Tbio

Novelty:  0.02680242

p_int:  0.999908377

p_ni:  0.000091623

Score:  0.999

Data Source:  BioPlex,STRINGDB

INTS8

Tdark

Novelty:  0.03933008

p_int:  0.9993821

p_ni:  0.000617899

p_wrong:  1e-9

Score:  0.9

Data Source:  BioPlex,STRINGDB

INTS5

Tbio

Novelty:  0.02127142

p_int:  0.997713737

p_ni:  0.002286262

p_wrong:  1e-9

Score:  0.999

Data Source:  BioPlex,STRINGDB

PRTFDC1

Tbio

Family:  Enzyme

Novelty:  0.13607881

p_int:  0.994267989

p_ni:  0.000385077

p_wrong:  0.005346934

Data Source:  BioPlex

BIRC6

Tbio

Novelty:  0.01187953

p_int:  0.994255667

p_ni:  0.005744333

Data Source:  BioPlex

FBXW5

Tbio

Novelty:  0.13100873

p_int:  0.98856269

p_ni:  0.000564028

p_wrong:  0.010873281

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (6)

Reactome (3)

WikiPathways (3)

Gene expression (Transcription) (R-HSA-74160)

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5

1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Gene expression (Transcription)	1452 targets	R-HSA-74160
Reactome	RNA Polymerase II Transcription	1314 targets	R-HSA-73857
Reactome	RNA polymerase II transcribes snRNA genes	71 targets	R-HSA-6807505

Name	Explore in Pharos	Explore in Source
Gene expression (Transcription)	1452 targets	R-HSA-74160
RNA Polymerase II Transcription	1314 targets	R-HSA-73857
RNA polymerase II transcribes snRNA genes	71 targets	R-HSA-6807505

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (16)

Functions (3)

Components (5)

Processes (8)

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10

1 – 3 of 3

GO Term	Evidence	Assigned by
G-rich strand telomeric DNA binding	Inferred from Direct Assay (IDA)	BHF-UCL
single-stranded DNA binding	Inferred from Direct Assay (IDA)	UniProtKB
DNA polymerase binding	Inferred from Physical Interaction (IPI)	BHF-UCL

Disease Associations (null)

No disease associations found

GWAS Traits (9)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 9

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
body height	EFO_0004339	5	9	18		99.6
body weight	EFO_0004338	2	2	2		74.2
appendicular lean mass	EFO_0004980	1	1	1		61.4
inflammatory skin disease	EFO_1000636	1	1	0	1.5	61.4
BMI-adjusted waist circumference	EFO_0007789	1	1	1		48.6

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 9

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
body height	EFO_0004339	18		99.6
body weight	EFO_0004338	2		74.2
appendicular lean mass	EFO_0004980	1		61.4
inflammatory skin disease	EFO_1000636	0	1.5	61.4
BMI-adjusted waist circumference	EFO_0007789	1		48.6

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Complete proteome
DNA damage
DNA repair
DNA-binding
Nucleus
Phosphoprotein
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
appendicular lean mass
BMI-adjusted waist circumference
body height
body weight
C-reactive protein measurement
inflammatory skin disease
psoriasis
risk-taking behaviour
type 2 diabetes mellitus

MGI Phenotype Find Similar Targets

No Header	No Header
cellular phenotype
craniofacial phenotype
digestive/alimentary phenotype
embryo phenotype
endocrine/exocrine gland phenotype
growth/size/body region phenotype
hearing/vestibular/ear phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
immune system phenotype

IDG Resources

No IDG generated resources found

Orthologs (8)

1 – 5 of 8

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Mouse	nucleic acid binding protein 2	MGI:1917167	69917
Rat	nucleic acid binding protein 2	RGD:1308158	362813
Dog	nucleic acid binding protein 2	VGNC:43602	474400
Horse	nucleic acid binding protein 2	VGNC:20540	100052155
Cow	nucleic acid binding protein 2	VGNC:31860	533842

Species	Name	OMA	EggNOG	Inparanoid
Mouse	nucleic acid binding protein 2
Rat	nucleic acid binding protein 2
Dog	nucleic acid binding protein 2
Horse	nucleic acid binding protein 2
Cow	nucleic acid binding protein 2

Publication Statistics

PubMed Score 15.25

PubMed score by year

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PubTator Score 25.53

PubTator score by year

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Related Publications

Text Mined References (17)

GeneRif Annotations (10)

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10

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PMID	Year	Title