Tbio NABP2 SOSS complex subunit B1

Protein Summary

Description

Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. Single-stranded DNA (ssDNA)-binding proteins, such as OBFC2B, are ubiquitous and essential for a variety of DNA metabolic processes, including replication, recombination, and detection and repair of damage (Richard et al., 2008 [PubMed 18449195]).[supplied by OMIM, Jun 2008]

Uniprot Accession IDs

• Q9BQ15
• A6NDF8
• Q6XYC8

Gene Name

• NABP2

Ensembl ID

• ENST00000267023
• ENSP00000267023
• ENSG00000139579
• ENST00000341463
• ENSP00000368862
• ENST00000380198
• ENSP00000369545

Symbol

• OBFC2B
• SSB1
• SSB1
• hSSB1
• OBFC2B
• SOSS-B1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
phenotype	0.86
cell type or tissue	0.83
transcription factor binding site profile	0.74
transcription factor perturbation	0.74
transcription factor	0.71

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Soss Complex Subunit B1

DTO Classes

Protein / Nucleic Acid Binding / Soss Complex Subunit B1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.25   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 116   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.25   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 116   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0