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Tbio
NABP1
SOSS complex subunit B2

Protein Summary
Description
Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. Single-stranded DNA (ssDNA)-binding proteins, such as OBFC2A, are ubiquitous and essential for a variety of DNA metabolic processes, including replication, recombination, and detection and repair of damage (Richard et al., 2008 [PubMed 18449195]).[supplied by OMIM, Jun 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307849
  • ENSP00000307968
  • ENSG00000173559
  • ENST00000409510
  • ENSP00000386605
  • ENST00000410026
  • ENSP00000387243
  • ENST00000425611
  • ENSP00000403683
  • ENST00000451500
  • ENSP00000390901

Symbol
  • OBFC2A
  • SSB2
  • SSB2
  • OBFC2A
  • SOSS-B2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
transcription factor perturbation
1
transcription factor binding site profile
0.92
histone modification site profile
0.75
microRNA
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.29   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 79   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.29   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 79   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (99)
INTS3
Tbio
Novelty:  0.13398603
Score:  0.999
Data Source:  STRINGDB
INTS5
Tbio
Novelty:  0.02127142
Score:  0.999
Data Source:  STRINGDB
INIP
Tbio
Novelty:  0.08511211
Score:  0.978
Data Source:  STRINGDB
INTS6
Tbio
Novelty:  0.02680242
Score:  0.97
Data Source:  STRINGDB
INTS11
Tbio
Novelty:  0.03333938
Score:  0.964
Data Source:  STRINGDB
INTS14
Tdark
Novelty:  1.33783374
Score:  0.944
Data Source:  STRINGDB
INTS2
Tbio
Novelty:  0.22178745
Score:  0.939
Data Source:  STRINGDB
INTS9
Tbio
Novelty:  0.06037786
Score:  0.938
Data Source:  STRINGDB
INTS13
Tbio
Novelty:  0.05454723
Score:  0.938
Data Source:  STRINGDB
RPRD2
Tdark
Novelty:  0.45063764
Score:  0.936
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
RNA Polymerase II Transcription
Reactome
RNA polymerase II transcribes snRNA genes
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
RNA Polymerase II Transcription
RNA polymerase II transcribes snRNA genes
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
3
5
87.2
neutrophil count
3
3
3
50
1
1
0
1.2
43.2
platelet count
3
1
3
16.7
reticulocyte measurement
2
1
2
10.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
5
87.2
neutrophil count
3
50
0
1.2
43.2
platelet count
3
16.7
reticulocyte measurement
2
10.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nucleic acid binding protein 1
VGNC:2053
744811
Mouse
MGI:1923258
109019
Rat
RGD:1306658
363227
Horse
nucleic acid binding protein 1
VGNC:51475
100069730
Cow
nucleic acid binding protein 1
VGNC:31859
613474
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nucleic acid binding protein 1
Mouse
Rat
Horse
nucleic acid binding protein 1
Cow
nucleic acid binding protein 1
Publication Statistics
PubMed Score 15.29
PubMed score by year
PubTator Score 6.32
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title