You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
NAB1
NGFI-A-binding protein 1

Protein Summary
Description
Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000337386
  • ENSP00000336894
  • ENSG00000138386
  • ENST00000409581
  • ENSP00000387089
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.88
ligand (protein) perturbation
0.83
histone modification site profile
0.81
microRNA
0.81
transcription factor perturbation
0.8


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.06   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 267   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.06   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 267   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (20)
NAB2
Tbio
Novelty:  0.00860107
p_int:  0.999999686
p_ni:  2.67e-7
p_wrong:  4.7e-8
Score:  0.36
Data Source:  BioPlex,STRINGDB
EGR1
Tbio
Family:  TF
Novelty:  0.00039994
p_int:  0.999781148
p_ni:  0.000054625
p_wrong:  0.000164227
Score:  0.882
Data Source:  BioPlex,STRINGDB
AKTIP
Tbio
Novelty:  0.00315951
p_int:  0.999010222
p_ni:  6.13e-7
p_wrong:  0.000989165
Score:  0.519
Data Source:  BioPlex,STRINGDB
ZNF362
Tdark
Family:  TF
Novelty:  0.03416924
Score:  0.893
Data Source:  STRINGDB
EGR4
Tbio
Family:  TF
Novelty:  0.02553936
Score:  0.776
Data Source:  STRINGDB
EGR2
Tbio
Family:  TF
Novelty:  0.00215433
Score:  0.754
Data Source:  STRINGDB
EGR3
Tbio
Family:  TF
Novelty:  0.00766779
Score:  0.675
Data Source:  STRINGDB
CHD4
Tchem
Family:  Epigenetic
Novelty:  0.00826969
Score:  0.572
Data Source:  STRINGDB
STAT2
Tbio
Family:  TF
Novelty:  0.00241454
Score:  0.572
Data Source:  STRINGDB
POU3F1
Tbio
Family:  TF
Novelty:  0.00290081
Score:  0.554
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.5
71.6
primary biliary cirrhosis
1
1
0
1.4
61.4
heel bone mineral density
2
2
2
60.4
2
2
0
1.2
48.3
2
2
0
1.1
48.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.5
71.6
primary biliary cirrhosis
0
1.4
61.4
heel bone mineral density
2
60.4
0
1.2
48.3
0
1.1
48.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NGFI-A binding protein 1
VGNC:2052
459832
Macaque
NGFI-A binding protein 1
693274
Mouse
MGI:107564
17936
Rat
RGD:70882
64824
Dog
NGFI-A binding protein 1
VGNC:43600
488447
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NGFI-A binding protein 1
Macaque
NGFI-A binding protein 1
Mouse
Rat
Dog
NGFI-A binding protein 1
Publication Statistics
PubMed Score 23.06
PubMed score by year
PubTator Score 10.65
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title